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Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium

Salmonella Typhimurium virulence is costly and can be lost by mutation during infection. Bakkeren et al. show that virulence restoration via horizontal gene transfer is only transient while transmission bottlenecks promote long-term virulence stability.

Erik Bakkeren
Ersin Gül
Médéric Diard
ResearchOpen Access11 Apr 2022
Nature Communications

Volume: 13, P: 1-13
A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

Salmonella mutants with reduced ability to colonize the mouse gut and cause disease are selected for by vaccine-induced intestinal antibody responses in mice.

Médéric Diard
Erik Bakkeren
Emma Slack
Research27 May 2021
Nature Microbiology

Volume: 6, P: 830-841
Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

The re-seeding of antibiotic-resistant persister subpopulations of Salmonella enterica into the gut lumen favours the transfer of resistance plasmids to gut-resident enterobacteria, showing that even small reservoirs of persister bacteria facilitate the spread of antibiotic resistance.

Erik Bakkeren
Jana S. Huisman
Wolf-Dietrich Hardt
Research04 Sept 2019
Nature

Volume: 573, P: 276-280
Evolutionary causes and consequences of bacterial antibiotic persistence

Antibiotic persistence is a threat to effective treatment of bacterial infections. In this Review, Bakkeren, Diard and Hardt discuss the evolutionary forces that have favoured the development of persisters in populations and the consequences for spread of resistance and virulence determinants.

Erik Bakkeren
Médéric Diard
Wolf-Dietrich Hardt
Reviews27 May 2020
Nature Reviews Microbiology

Volume: 18, P: 479-490
Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice

Short-term exposure to a high-fat diet reduces colonization resistance to Salmonella Typhimurium infection in mice and is associated with increase bile salts and plasmid transfer; however, E. coli can provide a protective effect under these conditions.

Sandra Y. Wotzka
Markus Kreuzer
Wolf-Dietrich Hardt
Research07 Oct 2019
Nature Microbiology

Volume: 4, P: 2164-2174
High-avidity IgA protects the intestine by enchaining growing bacteria

Oral-vaccine-induced IgA cross-links growing bacteria into clonal aggregates, inhibiting pathogenesis, adaption and the spread of antimicrobial resistance genes.

Kathrin Moor
Médéric Diard
Emma Slack
Research12 Apr 2017
Nature

Volume: 544, P: 498-502
Stabilization of cooperative virulence by the expression of an avirulent phenotype

A phenotypically avirulent subpopulation of the intestinal pathogen Salmonella typhimurium promotes evolutionary stability of virulence.

Médéric Diard
Victor Garcia
Wolf-Dietrich Hardt
Research20 Feb 2013
Nature

Volume: 494, P: 353-356
Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo

Fabienne Benz
Jana S. Huisman
Sebastian Bonhoeffer
ResearchOpen Access04 Nov 2020
The ISME Journal

Volume: 15, P: 862-878
Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

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Annika Hausmann
Desirée Böck
Wolf-Dietrich Hardt
ResearchOpen Access17 Jan 2020
Mucosal Immunology

Volume: 13, P: 530-544
Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution

Emma Slack
Médéric Diard
ReviewsOpen Access03 Nov 2022
Mucosal Immunology

Volume: 15, P: 1188-1198

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Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium

A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

Evolutionary causes and consequences of bacterial antibiotic persistence

Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice

High-avidity IgA protects the intestine by enchaining growing bacteria

Stabilization of cooperative virulence by the expression of an avirulent phenotype

Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution

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