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Showing 1–2 of 2 results
Advanced filters: Author: Mélanie Desbois Clear advanced filters

  • The exclusion of T cells from solid tumours is a potentially important mechanism that regulates whether or not cancer patients respond well to checkpoint blocking immunotherapies. Here the authors identify immune phenotypes and mediators of T cell exclusion among ovarian cancer patient samples from the ICON7 phase III trial.

    • Mélanie Desbois
    • Akshata R. Udyavar
    • Yulei Wang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The gut microbiota has been reported to regulate the efficacy of cancer therapy. Here, the authors show that short-chain fatty acids, which are generated through bacterial fermentation, increases immune tolerance leading to resistance to anti-CTLA-4 immunotherapy in mice and patients with metastatic melanoma.

    • Clélia Coutzac
    • Jean-Mehdi Jouniaux
    • Nathalie Chaput
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13