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Cell-type-specific and disease-associated expression quantitative trait loci in the human lung

Single-cell transcriptomics and expression quantitative trait locus mapping in 114 lung tissue samples, including 66 with interstitial lung disease, highlight the cell-type-specific functions of risk variants contributing to disease pathobiology.

Heini M. Natri
Christina B. Del Azodi
Nicholas E. Banovich
ResearchOpen Access28 Mar 2024
Nature Genetics

Volume: 56, P: 595-604
Author Correction: Cell-type-specific and disease-associated expression quantitative trait loci in the human lung

Heini M. Natri
Christina B. Del Azodi
Nicholas E. Banovich
Amendments and CorrectionsOpen Access25 Apr 2024
Nature Genetics

Volume: 56, P: 1034
Randomized phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer (NCT03093155): Updated survival and subgroup analyses

Dana M. Roque
Eric R. Siegel
Alessandro D. Santin
ResearchOpen Access20 Jun 2024
BJC Reports

Volume: 2, P: 1-7
Correction: Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer

Dana M. Roque
Eric R. Siegel
Alessandro D. Santin
Amendments and CorrectionsOpen Access04 Mar 2024
British Journal of Cancer

Volume: 130, P: 1073
Genomic prediction for agronomic traits in a diverse Flax (Linum usitatissimum L.) germplasm collection

Ahasanul Hoque
James V. Anderson
Mukhlesur Rahman
ResearchOpen Access08 Feb 2024
Scientific Reports

Volume: 14, P: 1-17
Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3

The authors show that loss-of-interaction with the nuclear importer, TNPO3, causes cytoplasmic mislocalization of RBM20 variants linked to severe cases of dilated cardiomyopathy. Restoring their nuclear localization alleviates the disease phenotype.

Julia Kornienko
Marta Rodríguez-Martínez
Lars M. Steinmetz
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-20
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Dilated cardiomyopathy is the second most common cause for heart failure. Here the authors combine CRISPR base editors with the muscle-targeting viral vector AAVMYO to repair patient mutations in the cardiac splice factor Rbm20 in two mouse models.

Markus Grosch
Laura Schraft
Lars M. Steinmetz
ResearchOpen Access22 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Mechanisms of plant acclimation to multiple abiotic stresses

A review summarizes the current understanding of the complex molecular pathways mediating plant responses to multiple abiotic stresses, and discusses current and future challenges and unanswered questions.

Zhang Jiang
Martijn van Zanten
Rashmi Sasidharan
ReviewsOpen Access24 Apr 2025
Communications Biology

Volume: 8, P: 1-15
Integrating protein interaction and pathway crosstalk network reveals a promising therapeutic approach for psoriasis through apoptosis induction

Masoumeh Farahani
Reza M. Robati
Saviz Saghari
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-16
Afatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro and in vivo

C L Schwab
S Bellone
A D Santin
ResearchOpen Access30 Sept 2014
British Journal of Cancer

Volume: 111, P: 1750-1756
Ectopic fat storage in the pancreas using ¹H-MRS: importance of diabetic status and modulation with bariatric surgery-induced weight loss

B Gaborit
I Abdesselam
A Dutour
Research21 Jul 2014
International Journal of Obesity

Volume: 39, P: 480-487
Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer

Dana M. Roque
Eric R. Siegel
Alessandro D. Santin
ResearchOpen Access11 Feb 2022
British Journal of Cancer

Volume: 126, P: 1695-1703
Mammaglobin B (SCGB2A1) is a novel tumour antigen highly differentially expressed in all major histological types of ovarian cancer: implications for ovarian cancer immunotherapy

S Bellone
R Tassi
A D Santin
ResearchOpen Access27 Jun 2013
British Journal of Cancer

Volume: 109, P: 462-471
Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy

S Bellone
D Roque
A D Santin
ResearchOpen Access24 Apr 2012
British Journal of Cancer

Volume: 106, P: 1543-1550
hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma

E Cocco
Z Hu
A D Santin
ResearchOpen Access10 Aug 2010
British Journal of Cancer

Volume: 103, P: 812-819
In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma

K El-Sahwi
S Bellone
A D Santin
ResearchOpen Access17 Nov 2009
British Journal of Cancer

Volume: 102, P: 134-143
Her2/neu extracellular domain shedding in uterine serous carcinoma: implications for immunotherapy with trastuzumab

P Todeschini
E Cocco
A D Santin
ResearchOpen Access13 Sept 2011
British Journal of Cancer

Volume: 105, P: 1176-1182
Serum amyloid A (SAA): a novel biomarker for uterine serous papillary cancer

E Cocco
S Bellone
A D Santin
ResearchOpen Access16 Jun 2009
British Journal of Cancer

Volume: 101, P: 335-341

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Cell-type-specific and disease-associated expression quantitative trait loci in the human lung

Author Correction: Cell-type-specific and disease-associated expression quantitative trait loci in the human lung

Randomized phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer (NCT03093155): Updated survival and subgroup analyses

Correction: Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer

Genomic prediction for agronomic traits in a diverse Flax (Linum usitatissimum L.) germplasm collection

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Mechanisms of plant acclimation to multiple abiotic stresses

Integrating protein interaction and pathway crosstalk network reveals a promising therapeutic approach for psoriasis through apoptosis induction

Afatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro and in vivo

Ectopic fat storage in the pancreas using ¹H-MRS: importance of diabetic status and modulation with bariatric surgery-induced weight loss

Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer

Mammaglobin B (SCGB2A1) is a novel tumour antigen highly differentially expressed in all major histological types of ovarian cancer: implications for ovarian cancer immunotherapy

Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy

hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma

In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma

Her2/neu extracellular domain shedding in uterine serous carcinoma: implications for immunotherapy with trastuzumab

Serum amyloid A (SAA): a novel biomarker for uterine serous papillary cancer

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