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Showing 51–100 of 106 results

Advanced filters: Author: M B A Heemskerk Clear advanced filters

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4⁺ T cells in human melanoma

Ton Schumacher and colleagues show that melanoma patients have CD4+ T cells reactive to mutated tumor antigens.

Carsten Linnemann
Marit M van Buuren
Ton N M Schumacher
Research22 Dec 2014
Nature Medicine

Volume: 21, P: 81-85
Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

Maria Escala-Garcia
Sander Canisius
Marjanka K. Schmidt
ResearchOpen Access05 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
The anatomy of a population-scale social network

Eszter Bokányi
Eelke M. Heemskerk
Frank W. Takes
ResearchOpen Access06 Jun 2023
Scientific Reports

Volume: 13, P: 1-16
Advancing the Integration of ‘Basic/Fundamental’ and Translational Cellular and Gene Therapy Science within the EBMT: Accelerating the Pathway to Progress

Donal P. McLornan
Mette D. Hazenberg
Anna Sureda
Reviews07 Aug 2025
Bone Marrow Transplantation

P: 1-6
Platelet biology and functions: new concepts and clinical perspectives

This Review provides an update of the latest developments in our understanding of platelet functions and populations in normal physiology and in haemorrhagic, thrombotic, and inflammatory conditions. These advancements can aid in tailoring new strategies to target platelets in disease states while avoiding the increased risk of bleeding associated with current antiplatelet therapies.

Paola E. J. van der Meijden
Johan W. M. Heemskerk
Reviews14 Nov 2018
Nature Reviews Cardiology

Volume: 16, P: 166-179
ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells

J Nigten
M C Breems-de Ridder
J H Jansen
Research03 Mar 2005
Leukemia

Volume: 19, P: 799-805
Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies

Jessie S. Kroonen
Ilona J. de Graaf
Alfred C. O. Vertegaal
ResearchOpen Access15 Feb 2023
Leukemia

Volume: 37, P: 864-876
HER2-low breast cancer shows a lower immune response compared to HER2-negative cases

Nadine S. van den Ende
Marcel Smid
Carolien H. M. van Deurzen
ResearchOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Treatment interval in curative treatment of colon cancer, does it impact (cancer free) survival? A non-inferiority analysis

Maud T. A. Strous
Charlotte J. L. Molenaar
F. Jeroen Vogelaar
Research12 Dec 2023
British Journal of Cancer

Volume: 130, P: 251-259
Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models

Eirikur Saeland
Leslie van der Fits
Roland C. Zahn
ResearchOpen Access23 Mar 2023
npj Vaccines

Volume: 8, P: 1-13
Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

Johanna P. van Geffen
Frauke Swieringa
Marijke J. E. Kuijpers
ResearchOpen Access08 Dec 2020
Scientific Reports

Volume: 10, P: 1-17
Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections

M. T. Heemskerk
C. J. Korbee
M. C. Haks
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-18
Multi-cistronic vector encoding optimized safety switch for adoptive therapy with T-cell receptor-modified T cells

M M van Loenen
R de Boer
M H M Heemskerk
Research31 Jan 2013
Gene Therapy

Volume: 20, P: 861-867
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Long-term maintenance of weight loss with sibutramine in a GP setting following a specialist guided very-low-calorie diet: a double-blind, placebo-controlled, parallel group study

E M H Mathus-Vliegen
Research28 Jul 2005
European Journal of Clinical Nutrition

Volume: 59, P: S31-S39
Remote digital monitoring in clinical trials in the time of COVID-19

Jennifer C. Goldsack
Elena S. Izmailova
John A. Wagner
News14 May 2020
Nature Reviews Drug Discovery

Volume: 19, P: 378-379
Reconstitution of adenovirus-specific cell-mediated immunity in pediatric patients after hematopoietic stem cell transplantation

G D Myers
C M Bollard
A M Leen
Research09 Apr 2007
Bone Marrow Transplantation

Volume: 39, P: 677-686
Molecular persistence of chronic myeloid leukemia caused by donor T cells specific for lineage-restricted maturation antigens not recognizing immature progenitor-cells

P A von dem Borne
S A P van Luxemburg-Heijs
J H F Falkenburg
Research09 Mar 2006
Leukemia

Volume: 20, P: 1040-1046
Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity

M J D van Tol
E C J Claas
M W Schilham
Research06 Apr 2005
Bone Marrow Transplantation

Volume: 35, P: S73-S76
Uncovering Offshore Financial Centers: Conduits and Sinks in the Global Corporate Ownership Network

Javier Garcia-Bernardo
Jan Fichtner
Eelke M. Heemskerk
ResearchOpen Access24 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines

Lisa te Molder
Maaike Kreft
Arnoud Sonnenberg
ResearchOpen Access21 Apr 2021
Scientific Reports

Volume: 11, P: 1-14
Adenovector 26 encoded prefusion conformation stabilized RSV-F protein induces long-lasting Th1-biased immunity in neonatal mice

Leslie van der Fits
Renske Bolder
Roland Zahn
ResearchOpen Access12 Jun 2020
npj Vaccines

Volume: 5, P: 1-9
T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome

T cell receptors (TCRs) enable the targeting of proteins selectively expressed by cancer cells, including neoantigens, cancer germline antigens and viral oncoproteins. This Review discusses the current cancer treatment landscape using TCRs and TCR-like molecules, including adoptive cell transfer of T cells expressing endogenous or engineered TCRs or TCR bispecific engagers.

Christopher A. Klebanoff
Smita S. Chandran
Antoni Ribas
Reviews27 Oct 2023
Nature Reviews Drug Discovery

Volume: 22, P: 996-1017
Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 disease

Krista E. van Meijgaarden
Suzanne van Veen
Frits Rosendaal
ResearchOpen Access05 Jun 2024
Scientific Reports

Volume: 14, P: 1-13
The importance of identifying a back-up donor for unrelated stem cell transplantation

S M van Walraven
M B A Heemskerk
M Oudshoorn
Research10 Jan 2005
Bone Marrow Transplantation

Volume: 35, P: 437-440
Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism

Mattijs M Heemskerk
Vanessa JA van Harmelen
Jan Bert van Klinken
Research27 May 2015
European Journal of Human Genetics

Volume: 24, P: 142-145
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Microparticles from apoptotic platelets promote resident macrophage differentiation

E M Vasina
S Cauwenberghs
R R Koenen
ResearchOpen Access29 Sept 2011
Cell Death & Disease

Volume: 2, P: e211
How to improve the search for an unrelated haematopoietic stem cell donor. Faster is better than more!

M B A Heemskerk
S M van Walraven
M Oudshoorn
Research21 Feb 2005
Bone Marrow Transplantation

Volume: 35, P: 645-652
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

Inge M. M. Lakeman
Alexandra J. van den Broek
Marjanka K. Schmidt
ResearchOpen Access10 Jun 2021
Genetics in Medicine

Volume: 23, P: 1726-1737
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Hisani N. Horne
Hannah Oh
Jonine D. Figueroa
ResearchOpen Access26 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
Genome-wide association study of germline variants and breast cancer-specific mortality

Maria Escala-Garcia
Qi Guo
Marjanka K. Schmidt
ResearchOpen Access21 Feb 2019
British Journal of Cancer

Volume: 120, P: 647-657
rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk

Jingjing Liu
Ivona Lončar
Antoinette Hollestelle
ResearchOpen Access15 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Highly diverged MHC class I mismatches are acceptable for haematopoietic stem cell transplantation

M B A Heemskerk
J J Cornelissen
M Oudshoorn
Research28 May 2007
Bone Marrow Transplantation

Volume: 40, P: 193-200
HGF/SF and its receptor c-MET play a minor role in the dissemination of human B-lymphoma cells in SCID mice

I S Weimar
K Weijer
W R Gerritsen
ResearchOpen Access13 Aug 1999
British Journal of Cancer

Volume: 81, P: 43-53
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Hatef Darabi
Jonathan Beesley
Alison M. Dunning
ResearchOpen Access07 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
HLA-DP as specific target for cellular immunotherapy in HLA class II-expressing B-cell leukemia

C E Rutten
S A P van Luxemburg-Heijs
J H F Falkenburg
Research17 Apr 2008
Leukemia

Volume: 22, P: 1387-1394
Two truncating variants in FANCC and breast cancer risk

Thilo Dörk
Paolo Peterlongo
Douglas F. Easton
ResearchOpen Access29 Aug 2019
Scientific Reports

Volume: 9, P: 1-14
Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

A Kmit
R van Kruchten
K Kunzelmann
ResearchOpen Access25 Apr 2013
Cell Death & Disease

Volume: 4, P: e611
The measured distance between tumor cells and the peritoneal surface predicts the risk of peritoneal metastases and offers an objective means to differentiate between pT3 and pT4a colon cancer

Emma S. Zwanenburg
Daniel D. Wisselink
Mandy Zournas
Research19 Sept 2022
Modern Pathology

Volume: 35, P: 1991-2001
MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage

N T T Thuong
T T B Tram
S J Dunstan
ResearchOpen Access17 Nov 2016
Genes & Immunity

Volume: 17, P: 419-425
Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

S Van Coppernolle
S Vanhee
B Vandekerckhove
Research04 Nov 2011
Leukemia

Volume: 26, P: 127-138
Unrelated donor marrow transplantation in children: transplant policy and outcome in Leiden Paediatrics SCT-Centre

J M Vossen
A E Donker
M Oudshoorn
Research18 May 2009
Bone Marrow Transplantation

Volume: 45, P: 87-95
Progress in therapeutic antisense applications for neuromuscular disorders

Annemieke Aartsma-Rus
Gert-Jan B van Ommen
Reviews07 Oct 2009
European Journal of Human Genetics

Volume: 18, P: 146-153
Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1

K Fleischhauer
M A Fernandez-Viña
S R Spellman
Research23 Jun 2014
Bone Marrow Transplantation

Volume: 49, P: 1176-1183
HLA class II restricted T-cell receptor gene transfer generates CD4⁺ T cells with helper activity as well as cytotoxic capacity

L T van der Veken
M Hoogeboom
M H M Heemskerk
Research21 Jul 2005
Gene Therapy

Volume: 12, P: 1686-1695
In vitro generation of mature, naive antigen-specific CD8⁺ T cells with a single T-cell receptor by agonist selection

S Snauwaert
G Verstichel
B Vandekerckhove
Research04 Oct 2013
Leukemia

Volume: 28, P: 830-841

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