Autosomal dominant polycystic kidney disease (ADPKD) is a progressive inherited disorder in which renal tissue is gradually replaced with fluid-filled cysts. Interestingly, improved understanding of the signalling and pathological derangements characteristic of ADPKD has revealed marked similarities to those of solid tumours. Here, the authors examine the pathological features and signalling pathways common to both ADPKD and cancer. Their analysis highlights potential avenues for further research and therapeutic potential in both diseases.
- Tamina Seeger-Nukpezah
- Daniel M. Geynisman
- Erica A. Golemis
