The higher incidence of multiple sclerosis (MS) in women than in men is widely acknowledged in the literature. The role of sex-related factors is, therefore, an important avenue for further investigation and for the development of novel therapeutic strategies for MS. In this Review, Voskuhl and Gold examine the effects of sex-related factors on MS susceptibility, activity and progression, and identify important areas for future research.
- Rhonda R. Voskuhl
- Stefan M. Gold
