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In this clinical study, the authors show that fecal microbiota transplantation is feasible and safe in adult women with anorexia nervosa, shifting gut bacteria toward a healthy donor profile and improving stool consistency after a single treatment.

Fire hydrants can create stagnant zones in drinking water systems that degrade water quality. This study shows that stagnant water has much higher metal and microbial levels than flowing water, revealing distinct chemical and microbial shifts that may pose health risks.

Here, a combination of forward genetics and genome-wide association analyses has been used to show that variation at a single genetic locus in Arabidopsis thaliana underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains the allele's persistence in natural populations throughout the world, even though it drastically reduces the production of new leaves.

Optical spin orientation of itinerant ferromagnets in twisted MoTe₂ homobilayers is demonstrated, enabling control of topological Chern numbers with circularly polarized light.

Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.

Kinematic measurements of the Perseus galaxy cluster reveal two drivers of gas motions: a small-scale driver in the inner core associated with black-hole feedback and a large-scale driver in the outer core powered by mergers.

Using activity-based chemical probes, oncogenic IDH1-R132H but not the wild type was found to acquire a unique autopalmitoylation at C269. This mutant-specific modification is critical for the enzyme’s abnormal activity in cancer.

Nanoporous metals offer the potential for tunability of electronic and optical properties. Here, the authors combine experimental studies and theoretical modeling to explore how nanoporous morphology shapes the intraband and interband contributions to the optical response of gold.

Active galactic nuclei are surrounded by a dusty and molecular disk that fuels supermassive black holes and connects them to their host galaxies. Here, the authors show with JWST interferometric observations that most of the dust in the Circinus galaxies lies in a compact disk, while only a tiny fraction traces hot outflowing material.

Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.

Organic additives frequently shape crystallisation in natural and industrial settings, yet their precise influence on nucleation remains poorly understood. Here, Baken et al. investigate how additives affect the crystallization of the industrially relevant minerals portlandite and gypsum. Using controlled titration coupled with in situ synchrotron monitoring, the team demonstrates that both minerals form via intermediate steps: portlandite gradually becomes more ordered as it develops, while gypsum switches abruptly from a disordered to an ordered state. The study reveals that additives influence these pathways prior to nucleation by altering the nature of prenucleation clusters. How strongly an additive interacts with these clusters depends on its chemical state, which is controlled by the pH conditions specific to each mineral. These findings offer a starting point for creating an industrial “toolbox” to help select more effective additives, and they advance our understanding of biomineralisation processes.

CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune response.

Multi-omics profiling of the mucosal mycobiome in individuals with Crohn’s disease identifies C. sphaerospermum as a protective fungal species that counteracts intestinal inflammation and reinforces the intestinal barrier.

How do low-mass binaries age? Astronomers have constrained a tight, circular orbit of a close-in companion around a dying giant star, raising new questions about how tidal forces shape binary orbits in the final phases of stellar evolution.

Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state.

This study assessed the durability of immunity in humans after vaccination with an MVA-based MERS vaccine. The data show that antibodies and T cells persist for at least two years, with the antibodies capable of cross-neutralizing MERS-CoV variants.

Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-range chemical signalling.

Risk associated with genetically defined forms of autism spectrum disorder (ASD) can propagate by means of transcriptional regulation to affect convergently dysregulated pathways, providing insight into the convergent impact of ASD genetic risk on human neurodevelopment.

Efficient nuclear delivery of DNA remains a major challenge in non-viral gene therapy. Here the authors present an improved workflow for generating DNA oligonucleotide-peptide conjugates which are ligated to linear DNA and achieve nuclear localization.

Currently polyphosphate kinases (PPKs), which catalyse phosphoryl transfer between polyphosphates and nucleotides, have restricted nucleotide substrate profiles. Here the authors discover and characterise a PPK capable of phosphorylating all eight common ribonucleotides.

A nine-year transit-timing campaign has measured the extremely low masses and densities of four large planets orbiting the young star V1298 Tau, which are now predicted to contract and form a typical compact super-Earth and sub-Neptune system.

A soft robotic probe enables continuous in utero monitoring of fetal physiological parameters, including heart rate, blood oxygen saturation, temperature and electrocardiogram data, during open or fetoscopic surgery to provide real-time information on fetal condition and distress.

CRISPR gene targeting in multicellular organisms results in genetic mosaics, limiting knockout efficiency. Here, the authors develop an improved system using Cas12a with multiple guides per gene, and demonstrate high accuracy and superior knockout efficiency in fruit flies.

Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recognize diverse Pse across several bacterial species, enabling mapping of the Pse glycoproteome and demonstrating therapeutic potential against multidrug-resistant Acinetobacter baumanii in in vitro and in vivo infection models.

De novo domestication was performed on the brassica Thlaspi arvense (pennycress) by identifying and stacking CRISPR-induced mutations to create a new intermediate oilseed crop that can be grown in the off-season, with seed compositions similar to canola (low erucic acid and reduced glucosinolate).

Engineered mucus-tethering bispecific nanobodies neutralize and entrap viruses to enhance mucosal immunity, preventing influenza infection and limiting SARS-CoV-2 transmission.

An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

Tropical forests regulate Earth’s carbon cycle, but what governs carbon sequestration following land use remains unclear. Here Tang et al find a shift from strong nitrogen limitation to no nutrient limitation over tropical forest secondary succession.

Stranded assets could pose a challenge to food system transformation. Estimates of the stranded agricultural assets that may arise from a shift to plant-based diets in the European Union and UK underscore the need to refocus support mechanisms for ensuring a just transition.

Geochemical data from zircons show that subduction-like processes were operating contemporaneously with stagnant-lid-like processes at different locations as early as 4.4 billion years ago on the Hadean Earth.

Optogenetic manipulation of spindle dynamics reveals that microtubule shortening at kinetochores limits spindle elongation rather than moving chromosomes, revealing local chromosome–spindle interactions.

Via high-throughput imaging and tracking over 140 million single mycobacteria, the authors show that drug- and strain-specific killing predict treatment outcomes, with potential to improve drug development and personalized therapy.

Whole-genome sequencing of polioviruses in Uganda following nOPV2 use showed high genetic stability and no sustained transmission, even though a rare double recombinant strain regained virulence, but did not spread due to high vaccination coverage.

Extracellular vesicles are central to immune regulation and stress responses. Here, the authors show how pathogen-derived compounds regulate host EV production showcasing new insight into how animals anticipate and prepare themselves for infection.

A 15-year prospective cohort study found that during times of social unrest in Hong Kong, people experienced more conflicts with family and friends and this coincided with the use of social media—these factors were also associated with higher levels of depression.

Natural killer cells can act as rheostats, or ‘master regulators’, controlling antiviral T-cell responses.

Albumin selectively inhibits Mucorales growth through the release of bound free fatty acids.

This study uses single-cell DNA sequencing to analyze genomic evolution in pancreatic cancer using a cohort of multiregionally and longitudinally sampled patients’ tissues across various clinical contexts.

Off-target activation of nerve fibers is an ongoing problem in bioelectronic medicines such as vagus nerve stimulation. Here, the authors show that high-frequency stimulation can selectively block nerve fibers in the vagus nerve in swine models.

Stepp and colleagues present hybrid-EDA, an event-driven acquisition (EDA) that enables gentle investigation of rare mitochondrial events. This approach combines continuous, low-phototoxicity phase-contrast surveillance with event-triggered fluorescence imaging, powered by dynamics-aware machine-learning event detection.

Differential isoform usage is identified with high statistical power from spatial transcriptomics data.

In a randomized phase 2 trial in patients with acute coronary syndrome and high levels of the inflammation biomarker C-reactive protein, treatment with low-dose interleukin-2 increased the numbers of regulatory T cells and reduced arterial inflammation, compared to placebo.

Species synchrony is considered a major mechanism of biodiversity–ecosystem stability relationships. Here, by combining theory, modelling and empirical work, the authors show that with time series length species synchrony decreases and its relationship with diversity switches from positive to negative.

The combination of JWST and ALMA data here unravel the history of the gas content of a quiescent galaxy, which became quenched through an act of self-sabotage. Black-hole accretion feedback heated the galaxy’s surrounding material, preventing its accretion.

Self-oscillators are critical in various natural and engineered systems, as they enable complex collective behaviors through interactions among individual units. This study demonstrates that populations of Quincke colloids-self-oscillators whose back-and-forth motion defines both a phase and a nematic oscillation axis-can achieve a form of collective order, termed synchronematic order, characterized by hydrodynamic interactions that synchronize their oscillation phases and align their orientations.

The detection of forsterite and enstatite emissions in EC 53 during accretion bursts marks one of the first pieces of direct evidence of in situ silicate crystallization in young stars.