Nature Search

Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases

Family D replicative DNA polymerases (PolD) contain a unique proofreading active site. Here, the authors present structures of PolD and enzymatic studies, revealing an unanticipated correction mechanism that extends the repertoire of protein domains known to be involved in DNA proofreading.

Leonardo Betancurt-Anzola
Markel Martínez-Carranza
Ludovic Sauguet
ResearchOpen Access14 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Cryptic phosphorylation in nucleoside natural product biosynthesis

Rather than their expected role in self-immunity, kinases encoded in the biosynthetic gene clusters of nucleoside natural products catalyze the phosphorylation of an early intermediate, a modification that is later removed in a downstream step.

Matthew M. Draelos
Anyarat Thanapipatsiri
Kenichi Yokoyama
Research30 Nov 2020
Nature Chemical Biology

Volume: 17, P: 213-221
Climate change-driven northward expansion of the mediterranean orchid Ophrys apifera from genetic and ecological perspectives

Aleksandra M. Naczk
Marcin Wilhelm
Marta Kolanowska
ResearchOpen Access13 Aug 2025
Scientific Reports

Volume: 15, P: 1-18
The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial

ATR/CHK1 pathway inhibitors represent a therapeutic option for platinum-resistant high-grade serous ovarian carcinoma (HGSOC). Here the authors report the results of a phase 2 clinical study of the CHK1 inhibitor prexasertib in patients with BRCA wild-type platinum-resistant HGSOC with or without biopsiable disease.

Elena Giudice
Tzu-Ting Huang
Jung-Min Lee
ResearchOpen Access30 Mar 2024
Nature Communications

Volume: 15, P: 1-14
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial

A safety and efficacy trial of a single intratumoral dose of the oncolytic adenovirus DNX-2401 followed by intravenous anti-PD-1 pembrolizumab in patients with recurrent glioblastoma shows an encouraging clinical benefit rate and 12 months overall survival.

Farshad Nassiri
Vikas Patil
Gelareh Zadeh
ResearchOpen Access15 May 2023
Nature Medicine

Volume: 29, P: 1370-1378
Mechanism for local attenuation of DNA replication at double-strand breaks

DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA synthesis.

Robin Sebastian
Eric G. Sun
Mirit I. Aladjem
Research19 Feb 2025
Nature

Volume: 639, P: 1084-1092
Next-generation characterization of the Cancer Cell Line Encyclopedia

The original Cancer Cell Line Encyclopedia (CCLE) is expanded with deeper characterization of over 1,000 cell lines, including genomic, transcriptomic, and proteomic data, and integration with drug-sensitivity and gene-dependency data.

Mahmoud Ghandi
Franklin W. Huang
William R. Sellers
Research08 May 2019
Nature

Volume: 569, P: 503-508
The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells

Andreas O. Mieland
Giuseppe Petrosino
Oliver H. Krämer
ResearchOpen Access29 Apr 2025
Leukemia

Volume: 39, P: 1756-1768
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer

Mismatch repair-deficient colorectal cancer clones adapt their mutation landscape by toggling homopolymer sequences in MutS homolog 3 (MSH3) and MutS homolog 6 (MSH6). This increases the subclonal mutation rate and clonal diversity, favoring immune escape and tumor growth.

Hamzeh Kayhanian
William Cross
Marnix Jansen
ResearchOpen Access03 Jul 2024
Nature Genetics

Volume: 56, P: 1420-1433
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

Inherited mutations in MUTYH have been shown to predispose patients to colorectal cancers. Here, the authors show that MUTYH mutations lead to an increased somatic base substitution mutation rate in normal intestinal epithelial cells, which is the likely cause for the increased cancer risk.

Philip S. Robinson
Laura E. Thomas
Michael R. Stratton
ResearchOpen Access08 Jul 2022
Nature Communications

Volume: 13, P: 1-12
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model

Idiopathic pulmonary fibrosis is a disease caused by persistent micro-injuries to the lung ultimately resulting in death. Here, the authors describe the use of a small molecule OGG1 inhibitor, TH5487, as a potent and potentially clinically relevant treatment for IPF.

L. Tanner
A. B. Single
A. Egesten
ResearchOpen Access06 Feb 2023
Nature Communications

Volume: 14, P: 1-16
Rapid effect of change in cerebrospinal fluid sodium concentration on salt appetite

R. S. WEISINGER
P. CONSIDINE
D. MOUW
Research01 Aug 1979
Nature

Volume: 280, P: 490-491
Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

Efficiency of transversion base editing is increased by matching a set of base editors to target sequences.

Luke W. Koblan
Mandana Arbab
David R. Liu
Research28 Jun 2021
Nature Biotechnology

Volume: 39, P: 1414-1425
Phyloecology of nitrate ammonifiers and their importance relative to denitrifiers in global terrestrial biomes

Nitrate ammonifiers are poorly known despite their importance for soil nitrogen retention. This study shows that they are phylogenetically diverse and globally distributed across terrestrial biomes and that the outcome of the competition with denitrifiers is controlled by soil nitrate.

Aurélien Saghaï
Grace Pold
Sara Hallin
ResearchOpen Access12 Dec 2023
Nature Communications

Volume: 14, P: 1-13
Cyclocryotherapy for chronic glaucoma after vitreoretinal surgery

C K L Chee
M P Snead
J D Scott
Research01 Jul 1994
Eye

Volume: 8, P: 414-418
Microbial diversity drives carbon use efficiency in a model soil

Microbial carbon use efficiency has an important role in soil C cycling. Here the authors test the interactive effects of temperature and moisture and manipulate microbial community composition in soil microcosms, showing a positive relationship between microbial diversity and CUE that is contingent on abiotic conditions.

Luiz A. Domeignoz-Horta
Grace Pold
Kristen M. DeAngelis
ResearchOpen Access23 Jul 2020
Nature Communications

Volume: 11, P: 1-10
Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer

X Cui
L Zhang
S M Dubinett
Research22 Jan 2007
Oncogene

Volume: 26, P: 4253-4260
Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours

In this Perspective, Holder et al. discuss the limitations of current predictive biomarkers of response to immune checkpoint inhibitors and the need to further explore static, dynamic and patient-specific biomarkers using novel tools, such as machine learning and consortia-level initiatives.

Ashley M. Holder
Aikaterini Dedeilia
Genevieve M. Boland
Reviews12 Jun 2024
Nature Reviews Cancer

Volume: 24, P: 498-512
In vivo CRISPR–Cas9 genome editing in mice identifies genetic modifiers of somatic CAG repeat instability in Huntington’s disease

A novel in vivo screening strategy identifies new modifiers of somatic CAG repeat expansion that contribute to age of onset in Huntington’s disease.

Ricardo Mouro Pinto
Ryan Murtha
Vanessa C. Wheeler
ResearchOpen Access22 Jan 2025
Nature Genetics

Volume: 57, P: 314-322
Genetic predisposition to colorectal cancer

Albert de la Chapelle
Reviews01 Oct 2004
Nature Reviews Cancer

Volume: 4, P: 769-780
THE DIAGNOSTIC SIGNIFICANCE OF IGG-COW'S MILK ANTI BODIES-REEVALUATED

Klaus M Keller
Annemarie Bürgin-Wolff
Stefan Wirth
Research01 Nov 1992
Pediatric Research

Volume: 32, P: 611
Incidence rates of classical Kaposi's sarcoma and multiple myeloma do not correlate

H Hjalgrim
M Frisch
M Melbye
Research01 Aug 1998
British Journal of Cancer

Volume: 78, P: 419-420
Integration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance

Herold et al. present an integrated meta-omics framework to investigate how mixed microbial communities, such as oleaginous bacterial populations in biological wastewater treatment plants, respond with distinct adaptation strategies to disturbances. They show that community resistance and resilience are a function of phenotypic plasticity and niche complementarity.

Malte Herold
Susana Martínez Arbas
Paul Wilmes
ResearchOpen Access19 Oct 2020
Nature Communications

Volume: 11, P: 1-14
The metabolic basis of epilepsy

In this Review, the authors highlight the growing recognition that disruptions in cellular metabolism can be both a cause and a consequence of epileptic seizures and discuss how this emerging science might be exploited to develop innovative therapeutic strategies.

Jong M. Rho
Detlev Boison
Reviews31 Mar 2022
Nature Reviews Neurology

Volume: 18, P: 333-347
Culexarchaeia, a novel archaeal class of anaerobic generalists inhabiting geothermal environments

Anthony J. Kohtz
Zackary J. Jay
Roland Hatzenpichler
ResearchOpen Access20 Sept 2022
ISME Communications

Volume: 2, P: 1-13
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer

Ilya G. Serebriiskii
Valerii A. Pavlov
Erica A. Golemis
ResearchOpen Access24 Nov 2023
npj Genomic Medicine

Volume: 8, P: 1-12
DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients

C Allera-Moreau
I Rouquette
C Cazaux
ResearchOpen Access22 Oct 2012
Oncogenesis

Volume: 1, P: e30
Enhanced sensitivity of the LIGO gravitational wave detector by using squeezed states of light

Squeezed states of light have been experimentally demonstrated to improve the performance of the Laser Interferometer Gravitational-wave Observatory (LIGO) in astrophysically relevant frequency regions. This enhanced performance may help to reach the sensitivity required for detecting gravitational waves.

J. Aasi
J. Abadie
J. Zweizig
Research21 Jul 2013
Nature Photonics

Volume: 7, P: 613-619
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes

Bibbin T. Paul
Lia Tesfay
Suzy V. Torti
ResearchOpen Access23 Dec 2019
Scientific Reports

Volume: 9, P: 1-13
The human herpesvirus-type 8 is not involved in malignant melanoma

M Deichmann
M Thome
H Näher
ResearchOpen Access26 Mar 1999
British Journal of Cancer

Volume: 80, P: 67-69
A prospective seroepidemiological study of human herpesvirus-8 infection and the risk of multiple myeloma

R Tedeschi
M Kvarnung
J Dillner
ResearchOpen Access03 Jan 2001
British Journal of Cancer

Volume: 84, P: 122-125
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase κ in colorectal cancer

F Lemée
C Bavoux
C Cazaux
Research13 Nov 2006
Oncogene

Volume: 26, P: 3387-3394
A gravitational wave observatory operating beyond the quantum shot-noise limit

‘Squeezed light’ enables quantum noise in one aspect of light to be reduced by increasing the noise, or more accurately the quantum uncertainty, of a complementary aspect. This has now been used to push the detectors at the heart of the GEO600 gravitational wave observatory to unprecedented levels of sensitivity.

J. Abadie
B. P. Abbott
J. Zweizig
Research11 Sept 2011
Nature Physics

Volume: 7, P: 962-965
Molecular Cloning of Exo–Cellobiohydrolase I Derived from Trichoderma Reesei Strain L27

S. Shoemaker
V. Schweickart
M. Innis
Research01 Oct 1983
Bio/Technology

Volume: 1, P: 691-696
Effects of the 5-HT₃ Antagonist, Ondansetron, on the Behavioral and Physiological Effects of Pentagastrin in Patients with Panic Disorder and Social Phobia

Una D McCann
Christina M Morgan
Robert M Post
Research01 Dec 1997
Neuropsychopharmacology

Volume: 17, P: 360-369
Lack of evidence of an association between HHV-8 and multiple myeloma

D Bouscary
N Dupin
V Calvez
Correspondence22 Oct 1998
Leukemia

Volume: 12, P: 1840-1841
Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity

J J Sutherland
Y W Webster
J L Stevens
ResearchOpen Access25 Apr 2017
The Pharmacogenomics Journal

Volume: 18, P: 377-390
A ‘DNA replication’ signature of progression and negative outcome in colorectal cancer

M-J Pillaire
J Selves
C Cazaux
Research09 Nov 2009
Oncogene

Volume: 29, P: 876-887
Multivalent immunity targeting tumor-associated antigens by intra-lymph node DNA-prime, peptide-boost vaccination

K A Smith
Z Qiu
A Bot
Research20 Aug 2010
Cancer Gene Therapy

Volume: 18, P: 63-76
Direct evidence for the role of microbial community composition in the formation of soil organic matter composition and persistence

Luiz A. Domeignoz-Horta
Melissa Shinfuku
Kristen M. DeAngelis
ResearchOpen Access06 Nov 2021
ISME Communications

Volume: 1, P: 1-4

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