Homeostatic plasticity is triggered by changes in somatic Ca2+ levels and the gamma secretase component presenilin 1 (PS1) is known to regulate intracellular Ca2+. Pratt et al. find that homeostatic synaptic plasticity is impaired in neurons lacking PS1 or expressing an Alzheimer's disease–linked PS1 mutation because of a deficit in kinase signaling unrelated to Ca2+ levels or gamma secretase activity.
- Kara G Pratt
- Eric C Zimmerman
- Jane M Sullivan
