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Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment

Viral infection is a common risk for immune-compromised individuals, particularly pediatric patients receiving hematopoietic stem cell transplants. Here the authors report a phase II trial testing adoptive transfer of third party, virus-specific T cells on the feasibility, safety, clinical responses, as well as homeostasis of antiviral immunity in the recipients.

Michael D. Keller
Patrick J. Hanley
Michael A. Pulsipher
ResearchOpen Access18 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

Mutations in the CD19 gene suggesting irreversible loss of its surface expression are identified in the majority of analyzed cases of CD19^– relapse in two clinical trials of pediatric ALL CD19 CAR T therapy, offering considerations for the rational choice of follow-up therapies.

Elena J. Orlando
Xia Han
Wendy Winckler
Research01 Oct 2018
Nature Medicine

Volume: 24, P: 1504-1506
Safety and feasibility of outpatient autologous stem cell transplantation in pediatric patients with primary central nervous system tumors

Jane Koo
Stacy Silverman
Jean M. Mulcahy Levy
ResearchOpen Access19 Feb 2019
Bone Marrow Transplantation

Volume: 54, P: 1605-1613
Factors predicting single-unit predominance after double umbilical cord blood transplantation

P Ramirez
J E Wagner
C G Brunstein
Research26 Sept 2011
Bone Marrow Transplantation

Volume: 47, P: 799-803
Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage

Dejene M. Tufa
Tyler Shank
Michael R. Verneris
ResearchOpen Access14 Apr 2020
Scientific Reports

Volume: 10, P: 1-12
Novel HLA-DP region susceptibility loci associated with severe acute GvHD

R K Goyal
S J Lee
R E Ferrell
Research05 Sept 2016
Bone Marrow Transplantation

Volume: 52, P: 95-100
A clofarabine-based bridging regimen in patients with relapsed ALL and persistent minimal residual disease (MRD)

N Gossai
M R Verneris
M J Burke
Research09 Dec 2013
Bone Marrow Transplantation

Volume: 49, P: 440-442
Ovarian function after hematopoietic cell transplantation: a descriptive study following the use of GnRH agonists for myeloablative conditioning and observation only for reduced-intensity conditioning

R Phelan
E Mann
A R Smith
Research06 Jun 2016
Bone Marrow Transplantation

Volume: 51, P: 1369-1375
Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies

T L Kindwall-Keller
Y Hegerfeldt
M J Laughlin
Research17 Oct 2011
Bone Marrow Transplantation

Volume: 47, P: 924-933
Similar outcomes between adolescent/young adults and children with AML following allogeneic hematopoietic cell transplantation

M J Burke
N Gossai
M R Verneris
Research04 Nov 2013
Bone Marrow Transplantation

Volume: 49, P: 174-178
Autologous stem cell transplantation for high-risk Ewing's sarcoma and other pediatric solid tumors

C J Fraser
B J Weigel
M R Verneris
Research07 Nov 2005
Bone Marrow Transplantation

Volume: 37, P: 175-181
Imatinib use either pre- or post-allogeneic hematopoietic cell transplantation (allo-HCT) does not increase cardiac toxicity in chronic myelogenous leukemia patients

M J Burke
B Trotz
M R Verneris
Research09 Feb 2009
Bone Marrow Transplantation

Volume: 44, P: 169-174
Lower leukemia relapse in pediatric patients with pulmonary cytolytic thrombi following allogeneic transplant

A R Smith
E Gulbahce
M R Verneris
Research14 Jun 2010
Bone Marrow Transplantation

Volume: 46, P: 368-371
YKL-40 in allogeneic hematopoietic cell transplantation after AML and myelodysplastic syndrome

B Kornblit
T Wang
P Garred
Research18 Jul 2016
Bone Marrow Transplantation

Volume: 51, P: 1556-1560
Donor and recipient plasma follistatin levels are associated with acute GvHD in Blood and Marrow Transplant Clinical Trials Network 0402

L M Turcotte
T E DeFor
S G Holtan
Research23 Oct 2017
Bone Marrow Transplantation

Volume: 53, P: 64-68
Allo-hematopoietic cell transplantation for Ph chromosome-positive ALL: impact of imatinib on relapse and survival

M J Burke
B Trotz
M R Verneris
Research08 Sept 2008
Bone Marrow Transplantation

Volume: 43, P: 107-113
Lymphodepleting chemotherapy with donor lymphocyte infusion post-allogeneic HCT for hematological malignancies is associated with severe, but therapy-responsive aGvHD

F He
E Warlick
D Weisdorf
Research11 Apr 2016
Bone Marrow Transplantation

Volume: 51, P: 1107-1112
Allogeneic hematopoietic cell transplantation outcomes for children with B-precursor acute lymphoblastic leukemia and early or late BM relapse

J C Beck
Q Cao
M J Burke
Research20 Sept 2010
Bone Marrow Transplantation

Volume: 46, P: 950-955
Low EGF in myeloablative allotransplantation: association with severe acute GvHD in BMT CTN 0402

S G Holtan
L F Newell
A Panoskaltsis-Mortari
Research05 Jun 2017
Bone Marrow Transplantation

Volume: 52, P: 1300-1303
Maternal hemoglobin concentration during pregnancy and risk of infant leukaemia: a children's oncology group study

A M Peters
C K Blair
J A Ross
ResearchOpen Access26 Sept 2006
British Journal of Cancer

Volume: 95, P: 1274-1276
Clinical outcomes of AML patients relapsing after matched-related donor and umbilical cord blood transplantation

N Bejanyan
B Oran
C Brunstein
Research02 Jun 2014
Bone Marrow Transplantation

Volume: 49, P: 1029-1035
No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia

Shahinaz M. Gadalla
Tao Wang
Sharon A. Savage
Research21 Dec 2017
Bone Marrow Transplantation

Volume: 53, P: 383-391
CD56^dimCD16⁺ NK cells downregulate CD16 following target cell induced activation of matrix metalloproteinases

B Grzywacz
N Kataria
M R Verneris
Correspondence24 Jan 2007
Leukemia

Volume: 21, P: 356-359
Donor body mass index does not predict graft versus host disease following hematopoietic cell transplantation

Lucie M. Turcotte
Tao Wang
Michael R. Verneris
Correspondence30 Jan 2018
Bone Marrow Transplantation

Volume: 53, P: 932-937
CD56^dimCD57⁺NKG2C⁺ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT

F Cichocki
S Cooley
J S Miller
Research29 Sept 2015
Leukemia

Volume: 30, P: 456-463
Directionality of non-permissive HLA-DPB1 T-cell epitope group mismatches does not improve clinical risk stratification in 8/8 matched unrelated donor hematopoietic cell transplantation

K Fleischhauer
K W Ahn
S R Spellman
Research05 Jun 2017
Bone Marrow Transplantation

Volume: 52, P: 1280-1287
Low day +100 serum epidermal growth factor levels are associated with acute GvHD after allogeneic hematopoietic cell transplantation

F He
M R Verneris
S G Holtan
Correspondence21 Nov 2016
Bone Marrow Transplantation

Volume: 52, P: 301-303
High-unbound mycophenolic acid concentrations in an infant on peritoneal dialysis following hematopoietic cell transplant

P A Jacobson
N Rydhom
M R Verneris
Correspondence27 Aug 2007
Bone Marrow Transplantation

Volume: 40, P: 911-912
Allogeneic hematopoietic cell transplantation (allo-HCT) outcomes for children with B-precursor ALL and early or late BM relapse

M J Burke
M R Verneris
J C Beck
Correspondence17 Jan 2011
Bone Marrow Transplantation

Volume: 46, P: 1571-1572

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