Patients hospitalized for heart failure (HF) have a high risk of postdischarge rehospitalization or mortality. Phase III trials of HF drugs have failed to show safety or efficacy, despite encouraging results from phase II studies. Muthiah Vaduganathan and colleagues overview five drug development programs for HF and discuss the importance of choosing the 'right' drug, target population, and clinical end points to optimize trial design.
- Muthiah Vaduganathan
- Stephen J. Greene
- Javed Butler
