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Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are key contributors to tau PET positivity, which should aid clinical decision-making and trial designs.

Rik Ossenkoppele
Emma M. Coomans
Oskar Hansson
ResearchOpen Access16 Jul 2025
Nature Neuroscience

Volume: 28, P: 1610-1621
The solution structure of a specific GAGA factor–DNA complex reveals a modular binding mode

James G. Omichinski
Paolo V. Pedone
G. Marius Clore
Research01 Feb 1997
Nature Structural Biology

Volume: 4, P: 122-132
Cholinergic network modulation in disinhibited eating behavior

Simultaneous PET-MRI measurements provide fundamental insights into the modulation of neural networks mediated by nicotinic acetylcholine receptors in human obesity as a putative biological mechanism for future weight loss interventions.

Swen Hesse
Michael Rullmann
Osama Sabri
ResearchOpen Access17 Sept 2025
Communications Biology

Volume: 8, P: 1-9
Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus

Yi Zhang
Gang Ji
Gene-Jack Wang
Research18 Jun 2018
International Journal of Obesity

Volume: 43, P: 842-851
Prefrontal and posterior parietal contributions to the perceptual awareness of touch

M. Rullmann
S. Preusser
B. Pleger
ResearchOpen Access18 Nov 2019
Scientific Reports

Volume: 9, P: 1-8
Adult attention-deficit/hyperactivity disorder is associated with reduced norepinephrine transporter availability in right attention networks: a (S,S)-O-[¹¹C]methylreboxetine positron emission tomography study

Christine Ulke
Michael Rullmann
Maria Strauß
ResearchOpen Access15 Nov 2019
Translational Psychiatry

Volume: 9, P: 1-10
Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1

CL Day
C Dupont
MG Hinds
Research24 Nov 1999
Cell Death & Differentiation

Volume: 6, P: 1125-1132
The central nervous norepinephrine network links a diminished sense of emotional well-being to an increased body weight

J Melasch
M Rullmann
B Pleger
Research20 Oct 2015
International Journal of Obesity

Volume: 40, P: 779-787
Serotonin transporter gene promoter methylation status correlates with in vivo prefrontal 5-HTT availability and reward function in human obesity

M Drabe
M Rullmann
S Hesse
ResearchOpen Access04 Jul 2017
Translational Psychiatry

Volume: 7, P: e1167
Sex differences in serotonin–hypothalamic connections underpin a diminished sense of emotional well-being with increasing body weight

J Melasch
M Rullmann
B Pleger
Research22 Apr 2016
International Journal of Obesity

Volume: 40, P: 1268-1277

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Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

The solution structure of a specific GAGA factor–DNA complex reveals a modular binding mode

Cholinergic network modulation in disinhibited eating behavior

Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus

Prefrontal and posterior parietal contributions to the perceptual awareness of touch

Adult attention-deficit/hyperactivity disorder is associated with reduced norepinephrine transporter availability in right attention networks: a (S,S)-O-[¹¹C]methylreboxetine positron emission tomography study

Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1

The central nervous norepinephrine network links a diminished sense of emotional well-being to an increased body weight

Serotonin transporter gene promoter methylation status correlates with in vivo prefrontal 5-HTT availability and reward function in human obesity

Sex differences in serotonin–hypothalamic connections underpin a diminished sense of emotional well-being with increasing body weight

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