Nature Search

Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Genetic mechanisms of blood pressure regulation remain poorly defined. Here, the authors perform a kidney multi-omics study to identify 399 kidney effector genes, 11 miRNAs and 97 proteins for blood pressure and hypertension.

Xiaoguang Xu
Chachrit Khunsriraksakul
Maciej Tomaszewski
ResearchOpen Access19 Mar 2024
Nature Communications

Volume: 15, P: 1-29
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Steve Brown and colleagues report an analysis of 20 phenotyping tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread pleiotropy and assign putative functions to genes that lacked previous phenotypic annotation.

Martin Hrabě de Angelis
George Nicholson
Steve D M Brown
Research27 Jul 2015
Nature Genetics

Volume: 47, P: 969-978
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

Christopher Abbosh
Nicolai J. Birkbak
Charles Swanton
Research26 Apr 2017
Nature

Volume: 545, P: 446-451
Specific expression of an elastase–human growth hormone fusion gene in pancreatic acinar cells of transgenic mice

David M. Ornitz
Richard D. Palmiter
Raymond J. MacDonald
Research14 Feb 1985
Nature

Volume: 313, P: 600-602
Field trial of a genetically improved baculovirus insecticide

Jennifer S. Cory>
Mark L. Hirst
David H. L. Bishop
Research14 Jul 1994
Nature

Volume: 370, P: 138-140
Comprehensive molecular characterization of mitochondrial genomes in human cancers

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Yuan Yuan
Young Seok Ju
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 342-352
Butler enables rapid cloud-based analysis of thousands of human genomes

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Biotechnology

Volume: 38, P: 288-292
Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments

Peter M. Steinert
Robert H. Rice
Alasdair C. Steven
Research28 Apr 1983
Nature

Volume: 302, P: 794-800
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.

Melusine Bleu
Swann Gaulis
Giorgio G. Galli
ResearchOpen Access20 Aug 2019
Nature Communications

Volume: 10, P: 1-10
Caskey to head Merck's genome efforts

C. M.
News27 Oct 1994
Nature

Volume: 371, P: 731
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations

Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

Boya Guo
Yanwei Cai
Burcu F. Darst
ResearchOpen Access01 Oct 2025
Nature Communications

Volume: 16, P: 1-16
The contribution of X-linked coding variation to severe developmental disorders

Developmental disorders (DDs) are more prevalent in males, thought to be due to X-linked genetic variation. Here, the authors investigate the burden of X-linked coding variants in 11,044 DD patients, showing that this contributes to ~6% of both male and female cases and therefore does not solely explain male bias in DDs.

Hilary C. Martin
Eugene J. Gardner
Matthew E. Hurles
ResearchOpen Access27 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Regulation of Pyrogallol Oxidations by Alcohols and Sugars

B. Z. SIEGEL
S. M. SIEGEL
N. S. GOODMAN
Research08 Jul 1961
Nature

Volume: 191, P: 180-181
The next best thing

A patient's tumour cells can be transplanted into a mouse to provide a model for analysis and drug testing. A panel of paediatric solid tumour models has been extensively characterized and made freely available. See Letter p.96

Mark A. Murakami
David M. Weinstock
News & Views30 Aug 2017
Nature

Volume: 549, P: 39-41
Origin of anti-parallelism in β-keratin

M. FEUGHELMAN
Research27 Mar 1986
Nature

Volume: 320, P: 314
Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

Grant Stewart, Andrew Jackson, Christopher Mathew, Fowzan Alkuraya and colleagues identify a novel replication fork protein, DONSON, which is important for maintaining genome stability. Mutations in DONSON cause microcephalic dwarfism and lead to stalled replication forks and DNA damage.

John J Reynolds
Louise S Bicknell
Grant S Stewart
Research13 Feb 2017
Nature Genetics

Volume: 49, P: 537-549
Fractionation of Lignin by Chromatography

DAVID E. BLAND
FREDA M. GATLEY
Research02 Jan 1954
Nature

Volume: 173, P: 32-33
mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

How cells adapt to glucose starvation is still elusive. Here, Levy et al. show that the mTOR substrate 4EBP1 protects human, mouse, and yeast cells from glucose starvation and is exploited by cancer cells to promote tumorigenesis.

Tal Levy
Kai Voeltzke
Gabriel Leprivier
ResearchOpen Access14 May 2024
Nature Communications

Volume: 15, P: 1-20
Infection breaks T-cell tolerance

Martin Röcken
Joseph F. Urban
Ethan M. Shevach
Research03 Sept 1992
Nature

Volume: 359, P: 79-82
A new look at nonparasitized red cells of malaria-infected monkeys

C. M. Gupta
A. Alam
G. P. Dutta
Research16 Sept 1982
Nature

Volume: 299, P: 259-261
Extensive fluvial surfaces at the East Antarctic margin have modulated ice-sheet evolution

Extensive flat surfaces observed beneath the East Antarctic Ice Sheet margin were formed by fluvial erosion and have modulated the ice-sheet response to climate change, according to an analysis of radio-echo sounding data.

Guy J. G. Paxman
Stewart S. R. Jamieson
Martin J. Siegert
ResearchOpen Access11 Jul 2025
Nature Geoscience

Volume: 18, P: 724-731
Carbon isotope evidence for the stepwise oxidation of the Proterozoic environment

David J. Des Marais
Harald Strauss
J. M. Hayes
Research15 Oct 1992
Nature

Volume: 359, P: 605-609
Benchmarking cell type and gene set annotation by large language models with AnnDictionary

Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

George Crowley
Robert C. Jones
Stephen R. Quake
ResearchOpen Access28 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

A method for de novo design of peptide macrocyles called RFpeptides has been developed. RFpeptides is an extension of RoseTTAFold2 and RFdiffusion and combines structure prediction and protein backbone generation for rapid and custom design of macrocyclic peptide binders.

Stephen A. Rettie
David Juergens
Gaurav Bhardwaj
ResearchOpen Access20 Jun 2025
Nature Chemical Biology

Volume: 21, P: 1948-1956
Direct evidence of homology between human DC-1 antigen and murine I-A molecules

M. Rosa Bono
Jack L. Strominger
Research28 Oct 1982
Nature

Volume: 299, P: 836-838
Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Matthew H. Bailey
William U. Meyerson
Christian von Mering
Amendments and CorrectionsOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1
Ras drives malignancy through stem cell crosstalk with the microenvironment

Aberrant crosstalk between cancer stem cells and their microenvironment triggers angiogenesis and TGFβ signalling, creating conditions that are conducive for hijacking leptin and leptin receptor signalling, which in turn launches downstream PI3K–AKT–mTOR signalling during the benign-to-malignant transition.

Shaopeng Yuan
Katherine S. Stewart
Elaine Fuchs
ResearchOpen Access30 Nov 2022
Nature

Volume: 612, P: 555-563
Increased Active Transport of Glucose through the Intestine during Pregnancy

J. LARRALDE
P. FERNANDEZ-OTERO
M. GONZALEZ
Research26 Mar 1966
Nature

Volume: 209, P: 1356-1357
Erratum: AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function

Ze Yang
Jun Jiang
Jiemin Wong
Amendments and Corrections01 Jul 2010
Cell Research

Volume: 20, P: 858
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

David Kägi
Birgit Ledermann
Hans Hengartner
Research05 May 1994
Nature

Volume: 369, P: 31-37
Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

Peter T. Lansbury Jr.
Philip R. Costa
Robert G. Griffin
Research01 Nov 1995
Nature Structural Biology

Volume: 2, P: 990-998
Characterizing a non-equilibrium phase transition on a quantum computer

Quantum computers may help to solve classically intractable problems, such as simulating non-equilibrium dissipative quantum systems. The critical dynamics of a dissipative quantum model has now been probed on a trapped-ion quantum computer.

Eli Chertkov
Zihan Cheng
Michael Foss-Feig
Research11 Sept 2023
Nature Physics

Volume: 19, P: 1799-1804
Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2

Cui et al. find that arginine depletion and inflammation reduces nuclear localization of arginyl-tRNA synthetase, which influences alternative splicing via condensate-like serine/arginine repetitive matrix protein 2, and regulates cellular metabolism and response to inflammation.

Haissi Cui
Jolene K. Diedrich
Paul Schimmel
Research14 Apr 2023
Nature Cell Biology

Volume: 25, P: 592-603
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1079
Angiogenic and immune predictors of neoadjuvant axitinib response in renal cell carcinoma with venous tumour thrombus

Venous tumour thrombus can occur within renal cell carcinoma, and can require complex additional surgery and treatment. Here, the authors analyse multiparametric data from patients treated with axitinib and develop a machine learning model to predict neoadjuvant treatment response.

Rebecca Wray
Hania Paverd
Robert J. Jones
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Initiation sites of Rous sarcoma virus RNA-directed DNA synthesis in vitro

Linda M. Cashion
R. H. Joho
C. Weissmann
Research01 Jul 1976
Nature

Volume: 262, P: 186-190
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1080
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1076
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

During aging, the levels of fibronectin in the muscle stem cell niche decline, contributing to age-related frailty, and supplementation restores youth-like muscle regeneration in mice.

Laura Lukjanenko
M Juliane Jung
C Florian Bentzinger
Research04 Jul 2016
Nature Medicine

Volume: 22, P: 897-905
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

High-throughput screening systems that better mimic the physiological complexity of diseased tissues may aid the discovery of more efficacious compounds. A co-culture system that mimics the microenvironment of leukemia stem cells (LSCs) in bone marrow enables the discovery of compounds, including lovastatin, that selectively kill LSCs.

Kimberly A Hartwell
Peter G Miller
Todd R Golub
Research27 Oct 2013
Nature Chemical Biology

Volume: 9, P: 840-848
Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics

The molecular mechanisms of cell entry for the recently identified highly pathogenic feline coronavirus FCoV-23 are characterized in detail.

M. Alejandra Tortorici
Annette Choi
David Veesler
ResearchOpen Access09 Jul 2025
Nature

Volume: 645, P: 235-243
Genomic landscape of multiple myeloma and its precursor conditions

The genomic features of precursor conditions of multiple myeloma provide multiple biological insights into disease origins and evolution, together with opportunities to identify those at highest risk of progression.

Jean-Baptiste Alberge
Ankit K. Dutta
Irene M. Ghobrial
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1493-1503
The young Sun and the atmosphere and photochemistry of the early Earth

V. M. Canuto
J. S. Levine
M. S. Giampapa
Research22 Sept 1983
Nature

Volume: 305, P: 281-286
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid

Retinoic acid is known to be effective against bone marrow metastatic neuroblastoma cells, but not primary tumors. Here, authors discover that bone morphogenetic protein signaling is responsible for determining neuroblastoma cell fate and sensitivity to retinoic acid.

Min Pan
Yinwen Zhang
Paul Geeleher
ResearchOpen Access28 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Adam M. Staffaroni
Melanie Quintana
Sónia Afonso
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2194-2206
Mice lacking ornithine–δ–amino–transferase have paradoxical neonatal hypoornithinaemia and retinal degeneration

Tao Wang
Ann M. Lawler
David Valle
Research01 Oct 1995
Nature Genetics

Volume: 11, P: 185-190
Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells

Anamaris M. Colberg-Poley
Stephan D. Voss
Peter Gruss
Research25 Apr 1985
Nature

Volume: 314, P: 713-718
Hormonal Control of Weight Gain in Infants Recovering from Protein Energy Malnutrition. I. The Effect of Insulin and Metabolic Rate

Hazel M Payne Robinson
Teresa Cocks
David Picou
Research01 Jan 1980
Pediatric Research

Volume: 14, P: 28-33

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