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Showing 1–7 of 7 results
Advanced filters: Author: M. Gabriele Bixel Clear advanced filters

  • Fractured long bones regenerate through osteo-angiogenic coupling, but how calvarial bone healing occurs is not yet clear. Here they show that regenerating blood vessels separate from co-migrating progenitors in calvarial bones, resulting in osteoblasts mineralizing a previously vascularized lesion.

    • M. Gabriele Bixel
    • Kishor K. Sivaraj
    • Ralf H. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to anti-osteoporosis treatments.

    • Vishal Mohanakrishnan
    • Kishor K. Sivaraj
    • Ralf H. Adams
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 2020-2034

  • Developmental and regenerative bone formation require the removal of chondrocytes and matrix. Here the authors show that these processes involve mesenchymal stromal cell-derived septoclasts, which disappear after the completion of development but re-emerge during fracture healing.

    • Kishor K. Sivaraj
    • Paul-Georg Majev
    • Ralf H. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mice rejuvenates the bone.

    • Saravana K. Ramasamy
    • Anjali P. Kusumbe
    • Ralf H. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, inducing the formation of vascular lesions in the brain.

    • Rodrigo Diéguez-Hurtado
    • Katsuhiro Kato
    • Ralf H. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • Langen et al. identify a third capillary endothelial cell subtype, termed type E, that supports embryonic and early postnatal bone formation, and show that endothelial integrin β1 and laminin α5 are required for bone angiogenesis and osteogenesis.

    • Urs H. Langen
    • Mara E. Pitulescu
    • Ralf H. Adams
    Research
    Nature Cell Biology
    Volume: 19, P: 189-201