Disruption of the tumour suppressor p53, a transcriptional activator with numerous growth-suppressive targets, is a fundamental event in the development of most cancers. Here, p53 is found to have another function, independent of its role in transcription, enhancing the earliest processing step of precursors for microRNAs that regulate genes affecting cell growth.
- Hiroshi I. Suzuki
- Kaoru Yamagata
- Kohei Miyazono
