Amyotrophic lateral sclerosis (ALS) involves a complex interaction between genetic susceptibility and environmental insults. In this Review, Paez-Colasante and colleagues discuss various disease mechanisms that might apply to ALS, with particular emphasis on epigenetic factors. To date, only one treatment even modestly improves survival in patients with ALS, and the authors discuss several potential new therapeutic targets.
- Ximena Paez-Colasante
- Claudia Figueroa-Romero
- Eva L. Feldman