Nature Search

LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages

Targeted nanodrug delivery is crucial to treat respiratory diseases, but profiling the delivery and dynamics of nanoparticles (NPs) within the lung is a challenging task. Here, the authors present LungVis 1.0, an AI-driven 3D imaging ecosystem to profile inhaled substances in distinct lung regions while uncovering the role of tissue-resident macrophages in the fate of NPs.

Lin Yang
Qiongliang Liu
Otmar Schmid
ResearchOpen Access27 Nov 2024
Nature Communications

Volume: 15, P: 1-22
Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division

Uropathogenic strains of Escherichia coli (UPEC) are a leading cause of urinary tract infections (UTIs) and invasion involves Rho GTPase members, notably Rac1, to drive actin cytoskeleton rearrangement leading to engulfment. Here, Petracchini et al. provide evidence of an ECM stiffnessmodulated role of Optineurin (OPTN), which regulates HACE1-dependant Rac1 activity and thus controls integrinmediated mechanotransduction and bacterial invasion.

Serena Petracchini
Daniel Hamaoui
Amel Mettouchi
ResearchOpen Access13 Oct 2022
Nature Communications

Volume: 13, P: 1-22
Revisiting Fragmentation Reactions of Protonated α-Amino Acids by High-Resolution Electrospray Ionization Tandem Mass Spectrometry with Collision-Induced Dissociation

Pengwei Zhang
Wan Chan
Terence C. W. Poon
ResearchOpen Access23 Apr 2019
Scientific Reports

Volume: 9, P: 1-10
Three-dimensional localization of ultracold atoms in an optical disordered potential

An experimental study of three-dimensional localization of ultracold atoms in controlled disorder provides evidence for behaviour that is consistent with Anderson localization, but incompatible with classical trapping.

F. Jendrzejewski
A. Bernard
P. Bouyer
Research04 Mar 2012
Nature Physics

Volume: 8, P: 398-403
MISATO: machine learning dataset of protein–ligand complexes for structure-based drug discovery

MISATO is a database for structure-based drug discovery that combines quantum mechanics data with molecular dynamics simulations on ~20,000 protein–ligand structures. The artificial intelligence models included provide an easy entry point for the machine learning and drug discovery communities.

Till Siebenmorgen
Filipe Menezes
Grzegorz M. Popowicz
ResearchOpen Access10 May 2024
Nature Computational Science

Volume: 4, P: 367-378
Biases in machine-learning models of human single-cell data

This Perspective discusses the various biases that can emerge along the pipeline of machine learning-based single-cell analysis and presents methods to train models on human single-cell data in order to assess and mitigate these biases.

Theresa Willem
Vladimir A. Shitov
Fabian J. Theis
Reviews19 Feb 2025
Nature Cell Biology

Volume: 27, P: 384-392
Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients

Elisa Masat
Pascal Laforêt
F. Zagnoli
ResearchOpen Access04 Nov 2016
Scientific Reports

Volume: 6, P: 1-13

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LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division

Revisiting Fragmentation Reactions of Protonated α-Amino Acids by High-Resolution Electrospray Ionization Tandem Mass Spectrometry with Collision-Induced Dissociation

Three-dimensional localization of ultracold atoms in an optical disordered potential

MISATO: machine learning dataset of protein–ligand complexes for structure-based drug discovery

Biases in machine-learning models of human single-cell data

Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients

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