Nature Search

Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

Integrative genomic and transcriptomic analyses reveal molecular events defining Richter transformation from CLL, and highlight the potential of cell-free DNA for early detection.

Erin M. Parry
Ignaty Leshchiner
Catherine J. Wu
Research09 Jan 2023
Nature Medicine

Volume: 29, P: 158-169
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia

Single-cell genomic and transcriptomic analyses of longitudinal samples of patients with Richter syndrome reveal the presence and dynamics of clones driving transformation from chronic lymphocytic leukemia years before clinical manifestation

Ferran Nadeu
Romina Royo
Elías Campo
ResearchOpen Access11 Aug 2022
Nature Medicine

Volume: 28, P: 1662-1671
Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation

Richter’s Transformation is a treatment-resistant and fatal progression from Chronic Lymphocytic Leukemia (CLL) to an aggressive lymphoma. Here, the authors show that PRMT5 is upregulated months prior to and after transformation, PRMT5 overexpression in a CLL mouse model leads to increased risk of transformation, and that targeted PRMT5 inhibition prolongs survival and delays disease development.

Zachary A. Hing
Janek S. Walker
Rosa Lapalombella
ResearchOpen Access06 Jan 2023
Nature Communications

Volume: 14, P: 1-21
Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

B. R. G. Williams
R. R. Golgher
I. M. Kerr
Research06 Dec 1979
Nature

Volume: 282, P: 582-586
A phase two study of high dose blinatumomab in Richter’s syndrome

Philip A. Thompson
Xianli Jiang
William G. Wierda
Research08 Aug 2022
Leukemia

Volume: 36, P: 2228-2232
Richter transformation in chronic lymphocytic leukemia (CLL)—a pooled analysis of German CLL Study Group (GCLLSG) front line treatment trials

O. Al-Sawaf
S. Robrecht
B. Eichhorst
Research17 Mar 2020
Leukemia

Volume: 35, P: 169-176
Incidence of Richter transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma in the targeted therapy era

Paul J. Hampel
Kari G. Rabe
Sameer A. Parikh
Research10 Dec 2024
Leukemia

Volume: 39, P: 503-507
Nature of the Gram-positive Complex in Micro-organisms

H. HENRY
M. STAGEY
ETHEL G. TEECE
Research15 Dec 1945
Nature

Volume: 156, P: 720-721
Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation

Heribert Playa-Albinyana
Fabian Arenas
Dolors Colomer
ResearchOpen Access28 Nov 2023
Leukemia

Volume: 38, P: 557-569
Global spatially explicit crop water consumption shows an overall increase of 9% for 46 agricultural crops from 2010 to 2020

Using the most recent Spatial Production Allocation Model 2020 crop data, agricultural green and blue water consumption is estimated. Water use increased by up to four-fifths for major crops in the past two decades.

Abebe D. Chukalla
Mesfin M. Mekonnen
Davy Vanham
ResearchOpen Access06 Oct 2025
Nature Food

P: 1-12
BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma

Warren Fiskus
Christopher P. Mill
Kapil N. Bhalla
ResearchOpen Access02 Mar 2021
Leukemia

Volume: 35, P: 2621-2634
Primary Digestive Richter's Syndrome

Marie Parrens
Bassem Sawan
Jean Philippe Merlio
Research01 May 2001
Modern Pathology

Volume: 14, P: 452-457
Outcomes of patients with Richter transformation who received no prior chemoimmunotherapy for their CLL

Adam S. Kittai
Ying Huang
Jennifer A. Woyach
CorrespondenceOpen Access20 Feb 2025
Blood Cancer Journal

Volume: 15, P: 1-5
Systematic review and meta-analysis of educational approaches to reduce cognitive biases among students

This systematic review and meta-analysis of 53 randomized controlled trials finds that educational interventions can help students reduce cognitive biases, with a small but statistically significant overall effect.

Ghassani Swaryandini
Jessica Graham
Michael Noetel
Research26 Aug 2025
Nature Human Behaviour

P: 1-29
Evidence of bias in estimations of earthquake size

Göran Ekström
Adam M. Dziewonski
Research24 Mar 1988
Nature

Volume: 332, P: 319-323
Interference between overlapping memories is predicted by neural states during learning

Interference from overlapping memories can cause forgetting. Here, the authors show using fMRI decoding approaches that spontaneous reactivation of older memories during new encoding leads to integration, and less interference, between overlapping items.

Avi J. H. Chanales
Nicole M. Dudukovic
Brice A. Kuhl
ResearchOpen Access25 Nov 2019
Nature Communications

Volume: 10, P: 1-12
Volcanic crisis reveals coupled magma system at Santorini and Kolumbo

Seismological and geodetic data are used together with a machine learning earthquake catalogue to reconstruct magma migration before and during the 2025 volcano–tectonic crisis at Santorini volcano, indicating a coupling between Santorini and Kolumbo.

Marius P. Isken
Jens Karstens
Christian Berndt
ResearchOpen Access24 Sept 2025
Nature

Volume: 645, P: 939-945
Effect of first-line treatment on second primary malignancies and Richter’s transformation in patients with CLL

C Maurer
P Langerbeins
B Eichhorst
Research02 May 2016
Leukemia

Volume: 30, P: 2019-2025
Telomere length is an independent predictor of survival, treatment requirement and Richter's syndrome transformation in chronic lymphocytic leukemia

D Rossi
C Lobetti Bodoni
M Ladetto
Research02 Apr 2009
Leukemia

Volume: 23, P: 1062-1072
NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia

NFAT2 is a transcription factor that has been linked with chronic lymphocytic leukaemia (CLL), but its functions in CLL manifestation are still unclear. Here the authors show, by analysing mouse CLL models and characterising biopsies from CLL patients, that NFAT2 is an important regulator for the anergic phenotype of CLL.

Melanie Märklin
Jonas S. Heitmann
Martin R. Müller
ResearchOpen Access02 Oct 2017
Nature Communications

Volume: 8, P: 1-14
Prolonged remission in a case of Richter's transformation of B-cell chronic lymphocytic leukaemia following adoptive immunotherapy

D Milojković
M Aldouri
S Devereux
Correspondence04 Sept 2006
Bone Marrow Transplantation

Volume: 38, P: 461-462
Hodgkin’s disease type Richter’s syndrome in chronic lymphocytic leukemia

S Juneja
D Carney
HM Prince
Correspondence14 May 1999
Leukemia

Volume: 13, P: 826-827
Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study

Surprisingly consistent replication failure of gray matter correlates of childhood maltreatment raises questions about publication bias in prior literature and about prevailing models linking maltreatment to brain structure in adult populations.

Janik Goltermann
Nils R. Winter
Udo Dannlowski
ResearchOpen Access16 Sept 2025
Nature Communications

Volume: 16, P: 1-14
DNA double-strand break end resection factors and WRN facilitate mitotic DNA synthesis in human cells

Mitotic DNA synthesis (MiDAS) has been proposed to utilize break-induced DNA replication, a form of homology-directed DNA repair (HDR). Here, the authors find that core DNA end-resection factors required for HDR, including MRE11, CtIP and BRCA1, and a RecQ family helicase, WRN, are essential for MiDAS.

Szymon A. Barwacz
Katrine Lundgaard
Ying Liu
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Reply to C.D. Richter

Johnathon Liddicoat
Kathleen Liddell
Michael M. Hopkins
Correspondence17 Feb 2020
European Journal of Human Genetics

Volume: 28, P: 537-538
Ibrutinib has some activity in Richter’s syndrome

S Giri
A Hahn
M G Martin
CorrespondenceOpen Access30 Jan 2015
Blood Cancer Journal

Volume: 5, P: e277
Ocular lymphoma with extrascleral extension as primary manifestation of Richter syndrome

P M Mota
W Dedes
S Hague
Correspondence16 Mar 2012
Eye

Volume: 26, P: 891-893
The molecular basis of the human serum paraoxonase activity polymorphism

Richard Humbert
David A. Adler
Clement E. Furlong
Research01 Jan 1993
Nature Genetics

Volume: 3, P: 73-76
Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target

Multi-omics can be used to characterise tumour and immune cell populations. Here the authors use multi-omics to characterise CLL blood and tissue samples and use prediction models for CLL TCR specificity and implicate interactions between galectin-9 and TIM3 as involved in CLL immune escape and propose galectin-9 as a possible immunotherapy target.

L. Llaó-Cid
JKL Wong
M. Seiffert
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-22
Events associated with Development of Lipid Plaques on Plasma Agar

JULIA T. WELD
WILLIAM M. O'LEARY
Research03 Aug 1963
Nature

Volume: 199, P: 510-511
Water scarcity and fish imperilment driven by beef production

Water use in river basins is an age-old resource-management question, but it is rare to quantify consumption by specific sectors. The Colorado River is being overused for beef and dairy production, endangering the entire river ecosystem.

Brian D. Richter
Dominique Bartak
Tara J. Troy
Research02 Mar 2020
Nature Sustainability

Volume: 3, P: 319-328
YAP charge patterning mediates signal integration through transcriptional co-condensates

Transcriptional condensates concentrate gene regulatory proteins to control gene activation. Meyer et al. demonstrate that charge-mediated co-condensation of YAP and the oppositely charged transcriptional scaffold Med1 drives transcriptional activation.

Kirstin Meyer
Klaus Yserentant
Orion D. Weiner
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Multiple cell cycle regulator alterations in Richter's transformation of chronic lymphocytic leukemia

F Cobo
A Martínez
E Campo
Comments & Opinion05 Jun 2002
Leukemia

Volume: 16, P: 1028-1034
Neural correlates of human fear conditioning and sources of variability in 2199 individuals

A large brain imaging study of over 2000 people worldwide shows that fear conditioning engages brain regions linked to emotion and attention, with differences in individuals with anxiety or depression and strong influences from task design.

Joaquim Radua
Hannah S. Savage
Miquel A. Fullana
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Autoregulation of Intake of Amino-Acids: Reversal of an ‘Unwise’ Dietary Preference in Rats Under Conditions Favourable for Learning

RONALD M. KRAUSS
JEAN MAYER
Research02 May 1964
Nature

Volume: 202, P: 463-464
Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism

Treatment strategy of solid tumors requires continuous development. Here the authors develop a Macrophage Drug Conjugate (MDC) platform by loading ferritin-drug complexes to macrophages. MDC transfers the ferritin to cancer cells via ‘TRAnsfer of Iron binding protein’ (TRAIN) process and reduces tumor volume in various mouse tumor models.

Bartlomiej Taciak
Maciej Bialasek
Magdalena Krol
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-30
Extraction and Purification of Calcitonin

A. BAGHDIANTZ
G. V. FOSTER
I. MacINTYRE
Research05 Sept 1964
Nature

Volume: 203, P: 1027-1028
Stimulation of Three Receptors in Labellar Chemosensory Hairs of Calliphora erythrocephala Mg. by Monovalent Salts

C. J. den OTTER
A. M. van der POEL
Research03 Apr 1965
Nature

Volume: 206, P: 31-32
Clay Minerals as Catalysts and Adsorbents

D. M. C. MACEWAN
Research31 Jul 1948
Nature

Volume: 162, P: 195-196
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Blood Anticoagulating System and Malignant Tumours

B. A. KUDRJASHOV
T. M. KALISHEVSKAYA
S. M. KOLOMINA
Research10 May 1969
Nature

Volume: 222, P: 548-550
Optimized seismic risk mitigation in pipeline routing using a metaheuristic GIS based approach

Sayyed Hadi Alavi
Mohammadreza Mashayekhi
Mohammadreza Zolfaghari
ResearchOpen Access25 Sept 2025
Scientific Reports

Volume: 15, P: 1-21
Observed Triplication of PKP

R. D. ADAMS
M. J. RANDALL
Research23 Nov 1963
Nature

Volume: 200, P: 744-745
Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons

Heterochromatin loss has been linked to aging and neurodegeneration. Here, the authors show that combined loss of HP1β and HP1γ in neurons results in de-repressesion of endogenous retroviruses, inflammation in glia including accumulation of complement C3, dendritic loss, and cognitive decline in mice.

A. G. Newman
J. Sharif
V. Tarabykin
ResearchOpen Access08 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Indications for haematopoietic cell transplantation and CAR-T for haematological diseases, solid tumours and immune disorders: 2025 EBMT practice recommendations

R. Greco
A. Ruggeri
A. Sureda
ResearchOpen Access09 Sept 2025
Bone Marrow Transplantation

P: 1-27
Low-Voltage Electron Beam Irradiation of Normal and 5-Bromouridine Deoxyriboside-Treated L-P₅₉ Mouse Fibroblast Cells In Vitro

ARTHUR COLE
RONALD M. HUMPHREY
WILLIAM C. DEWEY
Research24 Aug 1963
Nature

Volume: 199, P: 780-782
Seismic magnitude clustering is prevalent in field and laboratory catalogs

Clustering of earthquake magnitudes is actively debated. Here, the authors show statistically significant magnitude clustering present in many different field and laboratory catalogs at a wide range of spatial scales (mm to 1000 km).

Q. Xiong
M. R. Brudzinski
J. C. Hampton
ResearchOpen Access12 Apr 2023
Nature Communications

Volume: 14, P: 1-10
Mode of slip and crust–mantle interaction at oceanic transform faults

Earthquakes in the crust and mantle at transform faults are distinct yet coupled, with seismic swarms in the mantle apparently preceding large earthquakes, according to ocean-bottom seismic monitoring of the Blanco Transform Fault.

Václav M. Kuna
John L. Nábělek
Jochen Braunmiller
Research21 Jan 2019
Nature Geoscience

Volume: 12, P: 138-142
Implications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes

Dengue virus transmission by Ae. aegypti mosquitoes poses a significant public health threat, necessitating innovative control strategies. Here, the authors demonstrate that, while successive blood feeding increases earlier dengue virus dissemination, the inhibitory effects of Wolbachia remain strong, highlighting Wolbachia’s potential to disrupt dengue transmission under natural feeding conditions.

Rebecca M. Johnson
Mallery I. Breban
Chantal B. F. Vogels
ResearchOpen Access29 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Marine barite as a monitor of seawater strontium isotope composition

A. Paytan
M. Kastner
T. Herbert
Research02 Dec 1993
Nature

Volume: 366, P: 445-449

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