G protein-coupled receptors (GPCRs) are expressed in different cell types of the brain. Their joint network function remains unclear due to lack of molecular tools allowing functional dissection targeting a single type of GPCR. Here the authors use optogenetics and show how serotonergic 5-HT2A receptors act across excitatory and inhibitory neurons in mouse visual cortex.
- Ruxandra Barzan
- Beyza Bozkurt
- Dirk Jancke