mRNA display strategies such as random non-standard peptide integrated discovery (RaPID) system allow screening of large peptide libraries to identify reversible binding to a target of interest. Here, the authors develop a covalent version of this methodology, photocrosslinking-RaPID, allowing identification of peptides that efficiently covalently modify their target of choice via photoaffinity labelling.
- Yuteng Wu
- M. Teresa Bertran
- Louise J. Walport
