Nature Search

Novel type of murine B-cell lymphoma

LEWIS L. LANIER
MICHAEL LYNES
PETER J. WETTSTEIN
Research01 Feb 1978
Nature

Volume: 271, P: 554-555
Correction: Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

Matthew D Lynes
Luiz O Leiria
Yu-Hua Tseng
Amendments and Corrections01 Nov 2017
Nature Medicine

Volume: 23, P: 1384
Functional expression of a transfected murine class II MHC gene

Ronald N. Germain
Michael A. Norcross
David H. Margulies
Research10 Nov 1983
Nature

Volume: 306, P: 190-194
Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance

Elevated concentrations of the lipid 12,13-diHOME in neonatal faeces is associated with childhood atopy and asthma. Here, the authors identify bacterial epoxide hydrolase genes that produce this lipid, are more abundant in the gut microbiota of neonates who develop atopy and/or asthma and are associated with diminished immune tolerance.

Sophia R. Levan
Kelsey A. Stamnes
Susan V. Lynch
Research22 Jul 2019
Nature Microbiology

Volume: 4, P: 1851-1861
Light-responsive adipose-hypothalamus axis controls metabolic regulation

Light is essential for biological life. Here, the authors show blue light activates the photoreceptor Opsin3 in white fat, triggering a light-responsive metabolic circuit involving adipose-hypothalamus communication, which could potentially alleviate obesity-induced metabolic abnormalities.

Tadataka Tsuji
Vladimir Tolstikov
Yu-Hua Tseng
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-19
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism

Many beneficial effects of exercise are mediated by factors secreted from the exercising muscle, so-called myokines. Here, the authors identify what might be the first exercised-induced adipokine, TGF-β2, which is secreted from subcutaneous fat in response to exercise-induced increases in serum lactate levels and has beneficial metabolic effects in mice.

Hirokazu Takahashi
Christiano R. R. Alves
Laurie J. Goodyear
Research11 Feb 2019
Nature Metabolism

Volume: 1, P: 291-303
Unraveling the functional dark matter through global metagenomics

A computational approach to generate reference-free protein families from the sequence space in metagenomes reveals an enormously diverse functional space.

Georgios A. Pavlopoulos
Fotis A. Baltoumas
Nikos C. Kyrpides
ResearchOpen Access11 Oct 2023
Nature

Volume: 622, P: 594-602
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

Cold stimulation induces the synthesis and release of the lipid species 12,13-diHOME from brown adipose tissue. This ‘lipokine’ then acts on brown adipocytes to promote the uptake of fatty acids to fuel this cell type's heat production.

Matthew D Lynes
Luiz O Leiria
Yu-Hua Tseng
Research27 Mar 2017
Nature Medicine

Volume: 23, P: 631-637
ScreenDMT reveals DiHOMEs are replicably inversely associated with BMI and stimulate adipocyte calcium influx

A study of blood lipids in two cohorts using a new replication test, ScreenDMT, finds that people with lower BMI have higher levels of linoleic acid diols 12,13-diHOME and 9,10-diHOME, which upregulate adipocyte calcium influx.

Jonathan M. Dreyfuss
Vera Djordjilović
Matthew D. Lynes
ResearchOpen Access14 Aug 2024
Communications Biology

Volume: 7, P: 1-10
Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study

John A. F. Zupancic
Gui-shuang Ying
Gui-shuang Ying
Research28 Feb 2020
Journal of Perinatology

Volume: 40, P: 1100-1108
Early local immune defences in the respiratory tract

This Review provides a comprehensive overview of the early airway immune responses to infections. The authors discuss the stepwise engagement of distinct tiers of effector functions and how early airway immune responses are influenced by factors such as the environment, obesity and ageing.

Akiko Iwasaki
Ellen F. Foxman
Ryan D. Molony
Reviews28 Nov 2016
Nature Reviews Immunology

Volume: 17, P: 7-20

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