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Showing 1–4 of 4 results
Advanced filters: Author: Mabel San Roman Clear advanced filters

  • The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin protrusive force at the site of antigen extraction.

    • Anita Kumari
    • Judith Pineau
    • Paolo Pierobon
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear. Here the authors show that, in activated T cells, the Golgin GMAP210 specifically conveys LAT+ vesicles to immune synapse allowing proper T cell activation.

    • Andres Ernesto Zucchetti
    • Laurence Bataille
    • Claire Hivroz
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Plasmacytoid dendritic cells (pDCs) are known for their copious IFN-I production. Soumelis and colleagues show that functionally and transcriptomically distinct human pDC populations can be generated from a single microbial or cytokine stimulus.

    • Solana G. Alculumbre
    • Violaine Saint-André
    • Vassili Soumelis
    Research
    Nature Immunology
    Volume: 19, P: 63-75