Retinoic acid and arsenic induce the differentiation of acute promyelocytic leukemia (APL) cells and clinical responses in individuals with APL. Nasr and colleagues now show that by triggering the degradation of the PML-RARA oncogenic fusion protein retinoic acid and arsenic also deplete the leukemia initiating cells, accounting for disease remission in a mouse model of APL.
- Rihab Nasr
- Marie-Claude Guillemin
- Hugues de Thé
