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Showing 1–3 of 3 results
Advanced filters: Author: Maciej M Markiewski Clear advanced filters

  • This work identifies two phenotypically and functionally distinctive subtypes of extracellular vesicles (EVs) that derive from primary or metastasizing pulmonary lymphangioleiomyomatosis cells and establishes these EVs as a therapeutic target.

    • Anil Kumar Kalvala
    • Ashok Silwal
    • Magdalena Karbowniczek
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-22

  • Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell differentiation forming a regulatory loop that could underlie TSC tumorigenesis.

    • Jun-Hung Cho
    • Bhaumik Patel
    • Magdalena Karbowniczek
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Tumors often resist immune-mediated destruction because of the presence of suppressor cells. Lambris and colleagues show that activated complement C5a helps mediate this effect by recruiting myeloid suppressor cells to the tumor microenvironment.

    • Maciej M Markiewski
    • Robert A DeAngelis
    • John D Lambris
    Research
    Nature Immunology
    Volume: 9, P: 1225-1235