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Showing 1–2 of 2 results
Advanced filters: Author: Madelon Dijk Clear advanced filters

  • An integrated network of chaperones and protein degradation machineries called the proteostasis network (PN) is required to maintain protein homeostasis. Here the authors show that one of the components of the PN, the chaperonin TRiC, interacts with the core transcription-coupled nucleotide excision repair protein CSA to ensure its assembly into the CRLCSA complex.

    • Alex Pines
    • Madelon Dijk
    • Haico van Attikum
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • The transcription-coupled repair pathway removes transcription-blocking DNA lesions, but how transcription is restored following DNA repair is not clear. Here the authors reveal that the PAF1 complex, while dispensable for the repair process, restores transcription after DNA damage.

    • Diana van den Heuvel
    • Cornelia G. Spruijt
    • Martijn S. Luijsterburg
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19