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Showing 1–19 of 19 results
Advanced filters: Author: Mads F. Knudsen Clear advanced filters

  • On-surface synthesis of nanographenes proceeds differently on metals than on semiconductors or insulating substrates. Here, the authors perform substrate type-independent chemistry with atomic hydrogen acting as a catalyst in the intramolecular cyclodehydrogenation reaction of polyarenes, yielding atomically precise nanographenes.

    • Rafal Zuzak
    • Pawel Dabczynski
    • Szymon Godlewski
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • The Atlantic Multidecadal Oscillation strongly influences Northern Hemisphere climate, yet its primary driver is poorly understood. Knudsen et al.analyse proxy records from the past ~450 years and show that external forcing has dominated control of the oscillation since the termination of the Little Ice Age.

    • Mads Faurschou Knudsen
    • Bo Holm Jacobsen
    • Jesper Olsen
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8

  • Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.

    • C. M. Singleton
    • T. B. N. Jensen
    • M. Albertsen
    ResearchOpen Access
    Nature
    Volume: 649, P: 971-981

  • The origin of the Atlantic Multidecadal Oscillation, a semi-periodic variability of sea-surface temperature, is unknown. Knudsenet al.show that 55- to 70-year climate oscillations existed throughout the last 8,000 years, suggesting that the Atlantic Multidecadal Oscillation is a permanent feature of the Holocene climate induced by internal ocean variability.

    • Mads Faurschou Knudsen
    • Marit-Solveig Seidenkrantz
    • Antoon Kuijpers
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-8

  • Erosion rates and ice cover extent of present day fjords and summit plateau landscapes beyond the last deglaciation are virtually unknown. Here, the authors constrain the long-term denudation rates and glaciation history in west Greenland based on cosmogenic nuclides.

    • Astrid Strunk
    • Mads Faurschou Knudsen
    • Nicolaj K. Larsen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • A combination of animal studies, data from a clinical trial and insights from an observational cohort suggest that, in individuals with metabolic dysfunction-associated steatohepatitis, semaglutide improves liver histology by reverting patient proteomes to better mimic the proteome of individuals without the disease.

    • Maximilian Jara
    • Jenny Norlin
    • Lotte B. Knudsen
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 3128-3140

  • The contribution of surface processes to the long-term evolution of plateau surfaces on high-latitude passive margins is poorly understood. Here, the authors show that recent glacial erosion on plateaus in western Scandinavia was widespread and may have contributed substantially to the sediment flux to the oceans.

    • Jane L. Andersen
    • David L. Egholm
    • Sheng Xu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • The North Atlantic Oscillation influences climate in the Arctic region and northern Europe. Reconstructions of circulation patterns associated with the North Atlantic Oscillation from a 5,200-year-long lake sediment record suggest that the atmospheric circulation responded to significant transitions in Northern Hemisphere climate.

    • Jesper Olsen
    • N. John Anderson
    • Mads F. Knudsen
    Research
    Nature Geoscience
    Volume: 5, P: 808-812

  • There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a non-basal/squamous gene expression subtype are most likely to respond to treatment.

    • Ann Taber
    • Emil Christensen
    • Lars Dyrskjøt
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Drivers of physiological aging are also linked to the etiology of chronic obstructive pulmonary disease (COPD), including inflammation and senescence, both influenced by nicotinamide adenine dinucleotide (NAD+) metabolism. Norheim et al. performed a randomized controlled trial in patients with COPD, testing whether boosting NAD+ levels reduces airway inflammation.

    • Kristoffer L. Norheim
    • Michael Ben Ezra
    • Morten Scheibye-Knudsen
    ResearchOpen Access
    Nature Aging
    Volume: 4, P: 1772-1781

  • Plateaus separated by deeply incised fjords are hallmarks of glaciated passive continental margins. Computational experiments show that they arise from evolving feedbacks between topography, ice dynamics and erosion over millions of years.

    • David L. Egholm
    • John D. Jansen
    • Mads F. Knudsen
    Research
    Nature Geoscience
    Volume: 10, P: 592-597

  • Superflares are large explosive events on stellar surfaces, much larger than solar flares, but it remains unclear whether they share the same origin. Here, the authors analysed 48 superflare stars and determine the relation between their chromospheric activity and the occurrence of superflares.

    • Christoffer Karoff
    • Mads Faurschou Knudsen
    • Wei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.

    • Pål Rasmus Njølstad
    • Ole Andreas Andreassen
    • Kári Stefánsson
    Comments & Opinion
    Nature Genetics
    Volume: 51, P: 924-930