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Cell Death & Disease (2)
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Showing 1–4 of 4 results

Advanced filters: Author: Madushan Fernando Clear advanced filters

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

Here, the authors characterise the zinc finger protein ZNF827 as a single stranded DNA binding protein that accumulates at stalled replication forks to activate the ATR-CHK1 pathway and engage homologous-recombination mediated DNA repair.

Sile F. Yang
Christopher B. Nelson
Hilda A. Pickett
ResearchOpen Access12 Mar 2024
Nature Communications

Volume: 15, P: 1-15
Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells

Shivam Vora
Saptarshi Chatterjee
Brian Gabrielli
ResearchOpen Access08 Jan 2025
Cell Death & Disease

Volume: 16, P: 1-11
Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition

Shivam Vora
Ariel Andrew
Brian Gabrielli
ResearchOpen Access09 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-9
Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

Madushan Fernando
Pascal H. G. Duijf
Brian Gabrielli
ResearchOpen Access15 May 2021
Oncogenesis

Volume: 10, P: 1-11