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Apico-basal forces exerted by apoptotic cells drive epithelium folding

Apoptotic cell death is required for morphogenesis of the developing leg joint of fruitflies; using this model system, the authors show here that within apoptotic cells a transient pulling force exerted through a highly dynamic apico-basal myosin II cable-like structure acts as a mechanical signal to increase tissue tension and modify tissue shape.

Bruno Monier
Melanie Gettings
Magali Suzanne
Research21 Jan 2015
Nature

Volume: 518, P: 245-248
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila

Tissue folding is a critical process during developmental morphogenesis. Here, Gracia et al. use live imaging, laser ablation and in silico modelling to demonstrate that cells entering EMT generate orthogonal forces necessary to drive mesoderm invagination in Drosophila.

Mélanie Gracia
Sophie Theis
Magali Suzanne
ResearchOpen Access04 Jul 2019
Nature Communications

Volume: 10, P: 1-17
How cells dig a hole for themselves

Epithelial tissues cover our organs and play an important role as physical barriers. The conditions leading to spontaneous hole formation in monolayer epithelia, which challenge epithelial integrity, have now been revealed.

Tatiana Merle
Magali Suzanne
News & Views19 Dec 2022
Nature Physics

Volume: 19, P: 23-24
Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis

Cristina Manjón
Ernesto Sánchez-Herrero
Magali Suzanne
Research03 Dec 2006
Nature Cell Biology

Volume: 9, P: 57-63
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Solveig Gretarsdottir, Kari Stefansson and colleagues report a genome-wide association study for abdominal aortic aneurysm. They identified a variant located within the DAB2IP gene on 9q33 associated with risk of developing abdominal aortic aneurysm.

Solveig Gretarsdottir
Annette F Baas
Kari Stefansson
Research11 Jul 2010
Nature Genetics

Volume: 42, P: 692-697
Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Amendments and Corrections17 Jul 2020
Nature Biotechnology

Volume: 38, P: 1000
Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson’s disease

Rebecca Ting Jiin Loo
Lukas Pavelka
Lydia Yahia-Cherif
ResearchOpen Access26 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-12
Environmental noise exposure is associated with atherothrombotic risk

Magali Koczorowski
Nadine Bernard
Marianne Zeller
ResearchOpen Access24 Feb 2022
Scientific Reports

Volume: 12, P: 1-11
Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Correspondence18 Jun 2020
Nature Biotechnology

Volume: 38, P: 927-931

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Apico-basal forces exerted by apoptotic cells drive epithelium folding

Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila

How cells dig a hole for themselves

Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson’s disease

Environmental noise exposure is associated with atherothrombotic risk

Scalable and robust SARS-CoV-2 testing in an academic center

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