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Advanced filters: Author: Magda M. Maslon Clear advanced filters
  • The ubiquitin ligase Mdm2 promotes both proteolytic degradation of the tumour suppressor p53 and its translation. Fahraeus and colleagues report an additional layer of regulation: p53 mRNA binds directly to Mdm2 protein to inhibit ubiquitin ligase activity, promoting its own translation.

    • Marco M. Candeias
    • Laurence Malbert-Colas
    • Robin Fåhraeus
    Research
    Nature Cell Biology
    Volume: 10, P: 1098-1105