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Nature Genetics (3)
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Showing 1–5 of 5 results

Advanced filters: Author: Mahan Nekoui Clear advanced filters

Genetics of myocardial interstitial fibrosis in the human heart and association with disease

Genome-wide association analyses identify 11 loci associated with native myocardial T1 time, a marker of interstitial fibrosis, providing insights into the pathways involved in myocardial fibrosis and myofibroblast cell state acquisition.

Victor Nauffal
Paolo Di Achille
Steven A. Lubitz
Research20 Apr 2023
Nature Genetics

Volume: 55, P: 777-786
Deep learning of left atrial structure and function provides link to atrial fibrillation risk

In this study, a deep learning-based model of left atrial size in UK Biobank enabled genome-wide association studies in 35,049 healthy participants. Several lines of evidence, including the PITX2 locus, linked left atrial dysfunction to atrial fibrillation risk.

James P. Pirruccello
Paolo Di Achille
Patrick T. Ellinor
ResearchOpen Access21 May 2024
Nature Communications

Volume: 15, P: 1-17
Genetic analysis of right heart structure and function in 40,000 people

Genome-wide analyses of cardiac magnetic resonance imaging data identify loci associated with right heart structure and function. A polygenic predictor of right ventricular ejection fraction is associated with dilated cardiomyopathy risk.

James P. Pirruccello
Paolo Di Achille
Patrick T. Ellinor
Research13 Jun 2022
Nature Genetics

Volume: 54, P: 792-803
Deep learning enables genetic analysis of the human thoracic aorta

Genome-wide association analyses identify variants associated with thoracic aortic diameter. A polygenic score for ascending aortic diameter was associated with a diagnosis of thoracic aortic aneurysm in independent samples.

James P. Pirruccello
Mark D. Chaffin
Patrick T. Ellinor
Research26 Nov 2021
Nature Genetics

Volume: 54, P: 40-51
Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever

Matthew L. Boisen
Jessica N. Hartnett
Robert F. Garry
ResearchOpen Access12 Apr 2018
Scientific Reports

Volume: 8, P: 1-14