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Showing 1–2 of 2 results
Advanced filters: Author: Mahesh Aitha Clear advanced filters

  • Ligand detection is an essential component of pre-clinical drug development. Here, the authors develop an assay directly coupling protein ligand binding to the luminescence intensity of NanoLuc luciferase; enabling a compound discovery strategy for a broad spectrum of potential drug targets.

    • Daniel A. Ciulla
    • Patricia K. Dranchak
    • James Inglese
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Carbapenem-resistant bacteria pose a major health threat by expressing metallo-β-lactamases (MβLs), enzymes able to hydrolyse these life-saving drugs. Here the authors use biophysical and computational methods and show that different MβLs share the same reaction mechanism, suggesting new strategies for drug design.

    • María-Natalia Lisa
    • Antonela R. Palacios
    • Alejandro J. Vila
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11