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Showing 1–3 of 3 results
Advanced filters: Author: Maheshi Udugama Clear advanced filters

  • Chromatin remodellers usually mobilize or disassemble nucleosomes by translocating along the nucleosomal DNA at the H3-H4 interface. Here, the authors provide evidence chromatin remodeller INO80 translocates along DNA at the H2A-H2B interface and displaces DNA from the surface of H2A-H2B.

    • Sandipan Brahma
    • Maheshi I. Udugama
    • Blaine Bartholomew
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • INO80 chromatin remodeler plays important roles in transcription, DNA repair, recombination, and heterochromatin maintenance. Here the authors characterise the functional interplay between the actin-related proteins (Arps)  in INO80, showing that Arp8 and Arp4 module sense the DNA length separating nucleosomes and regulate nucleosome remodeling.

    • Sandipan Brahma
    • Mzwanele Ngubo
    • Blaine Bartholomew
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Recent studies have identified a number of oncogenic histone point mutations in different cancers. Here the authors provide evidence that H3.3 G34R substitution mutation, which is found in paediatric gliomas, causes changes in H3K9me3 and H3K36me3 by interfering with the KDM4 family of K9/K36 demethylases.

    • Hsiao P. J. Voon
    • Maheshi Udugama
    • Lee H. Wong
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10