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Showing 1–7 of 7 results
Advanced filters: Author: Makito Miyazaki Clear advanced filters

  • The influence that actin network density has on protein penetration and dynamics is unclear. The authors show that the density of actin networks determines how actin-binding proteins interact with and deform the network, and how specific protein functions are regulated by actin density.

    • Kei Yamamoto
    • Makito Miyazaki
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Recent advances in protein design have enabled the construction of higher-order structures, however, the assembly of diverse protein units into cohesive artificial structures akin to biological assembly systems, especially in tubular forms, remains elusive. Here, the authors report a method employing two distinct protein units to create tubular structures which demonstrate dynamic flexibility and reversible assembly similar to that of the cytoskeleton.

    • Masahiro Noji
    • Yukihiko Sugita
    • Yuta Suzuki
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Symmetric or asymmetric positioning of intracellular structures such as the nucleus and mitotic spindle steers various biological processes. Here authors use an in vitro model and show that a tug-of-war between centripetal actomyosin waves and percolation of bulk actomyosin network direct the positioning.

    • Ryota Sakamoto
    • Masatoshi Tanabe
    • Makito Miyazaki
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The forkhead box transcription factor Foxo1 is required for the maintenance of pluripotency in human embryonic stem cells. Here Koga et al.show that expression of another forkhead box transcription factor, Foxd1, promotes and indicates successful reprogramming of mouse embryonic fibroblasts.

    • Makito Koga
    • Mitsuhiro Matsuda
    • Miki Ebisuya
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • Two mutations affecting the sleep–wakefulness balance in mice are detected, showing that the SIK3 protein kinase is essential for determining daily wake time, and the NALCN cation channel regulates the duration of rapid eye movement sleep.

    • Hiromasa Funato
    • Chika Miyoshi
    • Masashi Yanagisawa
    Research
    Nature
    Volume: 539, P: 378-383

  • Cell-type diversity results from a series of binary cell fate decisions. Here, Matsuda et al.find that cells engineered with a Notch/Delta lateral inhibition circuit spontaneously bifurcate into Notch-active and Delta-positive subpopulations that are robust at the individual and population levels.

    • Mitsuhiro Matsuda
    • Makito Koga
    • Miki Ebisuya
    Research
    Nature Communications
    Volume: 6, P: 1-12