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Showing 1–4 of 4 results
Advanced filters: Author: Malaiyalam Mariappan Clear advanced filters

  • Tail-anchored proteins have a single transmembrane domain at their carboxy termini and are post-translationally targeted to the endoplasmic reticulum via the cytosolic ATPase TRC40. These authors identify a conserved protein complex called Bat3 complex that is recruited to ribosomes, interacts with the transmembrane domain of newly released tail-anchored proteins and transfers them to TRC40 for subsequent targeting to the endoplasmic reticulum.

    • Malaiyalam Mariappan
    • Xingzhe Li
    • Ramanujan S. Hegde
    Research
    Nature
    Volume: 466, P: 1120-1124

  • Nearly 5% of membrane proteins are 'tail-anchored' to the endoplasmic reticulum by a single carboxy-terminal transmembrane domain. These tail-anchored proteins are targeted post-translationally by the ATPase Get3, but the mechanism of recognition and targeting by Get3 is not known. Here, the crystal structures of yeast Get3 in a nucleotide-free 'open' state and a nucleotide-bound 'closed' state are presented.

    • Agnieszka Mateja
    • Anna Szlachcic
    • Robert J. Keenan
    Research
    Nature
    Volume: 461, P: 361-366