The pancreatic lineage is used as a model for embryonic-stem-cell differentiation, and shows that co-culture with organ-matched mesenchyme permits proliferation and self-renewal of progenitors, enabling an expansion of more than a million-fold for human endodermal cells with full retention of developmental potential.
- Julie B. Sneddon
- Malgorzata Borowiak
- Douglas A. Melton
