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Showing 1–3 of 3 results
Advanced filters: Author: Malte Wunderlich Clear advanced filters
  • Endogenous retroviruses (ERV) can induce immune responses and the control of these viruses uses immune mechanisms also involved in autoimmunity. Here, the authors characterize the control of ERVs in mice and show age-associated B cell control and nucleic acid sensing TLR pathway involvement.

    • Eileen Rauch
    • Timm Amendt
    • Philipp Yu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19
  • Mucosal associated invariant T (MAIT) cells reside in barrier organs, but their contribution to inflammatory processes in the kidneys is not fully known. Here authors find by single cell RNA sequencing that among the different MAIT cell subtypes found at steady state, a population with MAIT17 signature is expanded in both human crescentic glomerulonephritis and its mouse model, and these cells may play protective role in the disease.

    • Ann-Christin Gnirck
    • Marie-Sophie Philipp
    • Jan-Eric Turner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • Functional mutations identified in patients with androgen insensitivity syndrome, in the formin and actin nucleator DAAM2, uncover signal-regulated nuclear actin assembly at a steroid hormone receptor necessary for transcription.

    • Julian Knerr
    • Ralf Werner
    • Nadine C. Hornig
    Research
    Nature
    Volume: 617, P: 616-622