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Advanced filters: Author: Malvika Sharan Clear advanced filters

Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection

This study reports a microscopy-based screen to find microRNAs (miRNAs) that control infection by Salmonella and Shigella, showing they have different requirements. Two miRNAs decrease Shigella actin motility through N-WASP and one miRNA inhibits Salmonella by targeting TGS2, a regulator of phagolysosomal trafficking.

Carmen Aguilar
Ana Rita Cruz
Ana Eulalio
Research02 Dec 2019
Nature Microbiology

Volume: 5, P: 192-205
Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection

The functional role of microRNAs in the interplay between bacterial pathogens and host cells is not well defined. Here, using an image-based high-throughput screening approach, the authors identify a family of microRNAs that regulates Salmonellainfection and characterize their mechanism of action.

Claire Maudet
Miguel Mano
Ana Eulalio
Research22 Aug 2014
Nature Communications

Volume: 5, P: 1-13
A systematic analysis of the RNA-targeting potential of secreted bacterial effector proteins

Caroline Tawk
Malvika Sharan
Jörg Vogel
ResearchOpen Access24 Aug 2017
Scientific Reports

Volume: 7, P: 1-14

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