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Advanced filters: Author: Mamoun M. Alhamadsheh Clear advanced filters

Development and preclinical testing of a naloxone prodrug depot for extended protection against opioid overdose

The opioid antidote naloxone used to treat opioid overdoses has a short duration of action requiring repeated doses. Here the authors develop an extended release naloxone prodrug delivery system and report the preclinical testing in rat and cynomolgus monkey models.

Hala Aldawod
Arjun D. Patel
Mamoun M. Alhamadsheh
ResearchOpen Access23 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects

The current peripherally acting mu-opioid receptor antagonists present limited permeability and pharmacokinetic properties. Here, the authors develop a drug delivery approach based on AG10, which demonstrates the impact of mu-opioid receptors in the central nervous system in precipitating opioid-induced constipation.

Md Tariqul Haque Tuhin
Dengpan Liang
Mamoun M. Alhamadsheh
ResearchOpen Access23 Jun 2022
Nature Communications

Volume: 13, P: 1-15
A biomimetic approach for enhancing the in vivo half-life of peptides

Linking a peptide with a small-molecule ligand for the serum protein transthyretin ensures half-life extension without diminishing potency through protection against proteases and decreasing glomerular filtration.

Sravan C Penchala
Mark R Miller
Mamoun M Alhamadsheh
Research07 Sept 2015
Nature Chemical Biology

Volume: 11, P: 793-798

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