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Showing 1–3 of 3 results
Advanced filters: Author: Man-Cheng Tang Clear advanced filters

  • Antibiotic-producing organisms need to co-evolve self-protection mechanisms to avoid any damage to themselves caused by the antibiotic pharmacophore (the reactive part of the compound). In this study, the authors report a self-defense strategy in naphthyridinomycin (NDM)-producing Streptomyces lusitanus, that comprises reductive inactivation of the hemiaminal pharmacophore by short-chain dehydrogenases/reductases (SDRs) NapW and HomW.

    • Wan-Hong Wen
    • Yue Zhang
    • Gong-Li Tang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Analysis of two homologous groups of fungal pericyclases demonstrates how they can catalyse either an Alder-ene reaction—which has not previously been found in nature—or a hetero-Diels–Alder reaction.

    • Masao Ohashi
    • Cooper S. Jamieson
    • Yi Tang
    Research
    Nature
    Volume: 586, P: 64-69