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Showing 1–8 of 8 results
Advanced filters: Author: Manasi Agrawal Clear advanced filters

  • By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing mechanism that explains the retention of this intron segment in a translated mRNA.

    • Suzhou Yang
    • Denethi Wijegunawardana
    • Junjie U. Guo
    Research
    Nature Neuroscience
    Volume: 28, P: 2034-2043

  • Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

    • Damaris K. Kinyoki
    • Jennifer M. Ross
    • Simon I. Hay
    ResearchOpen Access
    Nature Medicine
    Volume: 26, P: 750-759

  • Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID). Here, the authors review evidence on the preclinical phase of IBD, outlining and describing the proposed at-risk, initiation and expansion phases. Overlap with other IMIDs is discussed alongside the possible future directions for research into preclinical IBD.

    • Jonas J. Rudbaek
    • Manasi Agrawal
    • Tine Jess
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 21, P: 86-100

  • The appendix is thought to have a role in the pathogenesis of ulcerative colitis but the association remains unclear. In this Perspective, the authors consider the biology of the appendix with respect to its immunological function and the microbiome, and how this relates to its possible involvement in ulcerative colitis.

    • Manasi Agrawal
    • Kristine H. Allin
    • Jean-Frederic Colombel
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 20, P: 615-624

  • Multiomics advance our understanding of disease progression and can facilitate drug discovery. In this Perspective, current knowledge and applications of omics platforms in inflammatory bowel disease diagnosis and in identifying risk factors are discussed.

    • Manasi Agrawal
    • Kristine H. Allin
    • Tine Jess
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 399-409

  • This Comment article from the Precision Immunology Institute at the Icahn School of Medicine (PrIISM), New York, describes their efforts to provide critical reviews of COVID-19 articles posted daily on the preprint servers bioRxiv and medRxiv.

    • Nicolas Vabret
    • Robert Samstein
    • Uri Laserson
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 20, P: 338