The blood-brain barrier (BBB) restricts systemically delivered therapeutic antibodies into the brain. Here the authors engineer antibody Fc region to promote the binding to BBB expressed neonatal Fc receptor (FcRn) at neutral pH, therefore improving brain penetration and brain targeting efficacy both in mice and non-human primates.
- Julien Lafrance-Vanasse
- Shraddha S. Sadekar
- Jasvinder K. Atwal
