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Coordination of virulence factors and lifestyle transition in Pseudomonas aeruginosa through single-cell analysis

Pseudomonas aeruginosa coordinates several virulence factors – the type 3 and H1-6 secretion systems and the flagellum – on a single cell level using the second messenger cyclic di-GMP, promoting subpopulations with distinct virulence states.

Haozhe Chen
Gabriele Malengo
Andreas Diepold
ResearchOpen Access16 Aug 2025
Communications Biology

Volume: 8, P: 1-14

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Coordination of virulence factors and lifestyle transition in Pseudomonas aeruginosa through single-cell analysis

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