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Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial

Vaccination provides protection from COVID-19, but optimization in design and route is an ever-ongoing process. Here the authors pursue an open-label, multi-arm phase I clinical trial to report the safety of a multi-valent, aerosol vaccine administered via inhalation, as well as superior mucosal immunity induced by ChAd over HuAd vectors.

Mangalakumari Jeyanathan
Sam Afkhami
Zhou Xing
ResearchOpen Access02 Jul 2025
Nature Communications

Volume: 16, P: 1-21
Author Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

Mangalakumari Jeyanathan
Maryam Vaseghi-Shanjani
Zhou Xing
Amendments and CorrectionsOpen Access09 May 2023
Nature Immunology

Volume: 24, P: 1049
A next-generation inhalable dry powder COVID vaccine

Current injectable COVID-19 vaccines are unable to induce robust immunity in the mucosal tissues lining the airways. A protein-based vaccine delivered to the lungs in the form of an inhaled dry powder shows promise as a way forward.

Zhou Xing
Mangalakumari Jeyanathan
News & Views13 Dec 2023
Nature

Volume: 624, P: 532-534
Immunological considerations for COVID-19 vaccine strategies

This Review outlines the guiding immunological principles for the design of coronavirus disease 2019 (COVID-19) vaccine strategies and analyses the current COVID-19 vaccine landscape and the challenges ahead.

Mangalakumari Jeyanathan
Sam Afkhami
Zhou Xing
Reviews04 Sept 2020
Nature Reviews Immunology

Volume: 20, P: 615-632
Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

Parenteral BCG vaccination has been shown to drive innate immune memory responses that can affect the response to pathogens other than mycobacteria. Here the authors show an innate immune memory mechanism whereby subcutaneous BCG vaccination alters the intestinal microbiome and in turn can train alveolar macrophages in the lungs.

Mangalakumari Jeyanathan
Maryam Vaseghi-Shanjani
Zhou Xing
ResearchOpen Access01 Dec 2022
Nature Immunology

Volume: 23, P: 1687-1702
Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis

Siamak Haddadi
Niroshan Thanthrige-Don
Zhou Xing
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice

Sam Afkhami
Michael R. D’Agostino
Zhou Xing
ResearchOpen Access23 Feb 2023
npj Vaccines

Volume: 8, P: 1-17

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Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial

Author Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

A next-generation inhalable dry powder COVID vaccine

Immunological considerations for COVID-19 vaccine strategies

Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis

Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice

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Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial

Author Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

A next-generation inhalable dry powder COVID vaccine

Immunological considerations for COVID-19 vaccine strategies

Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis

Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice

Search

Quick links