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Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study

Manja Schoenmaker
Anton J M de Craen
Rudi G J Westendorp
Research26 Oct 2005
European Journal of Human Genetics

Volume: 14, P: 79-84
Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization

Intracellular Salmonella enterica uses a type III secretion system to secrete more than 30 effector proteins into host cells. Here, Newson et al. generate six mutant strains deficient in different sets of effectors, thus providing insights on the interdependency or functional redundancy between effectors in vivo.

Joshua P. M. Newson
Flavia Gürtler
Wolf-Dietrich Hardt
ResearchOpen Access06 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Context-dependent change in the fitness effect of (in)organic phosphate antiporter glpT during Salmonella Typhimurium infection

Here, Santamaria de Souza et al. explore the context-dependent fitness effects of glpT-deficiency in Salmonella enterica, showing mutants thrive in the gut lumen but are counter-selected by macrophages, highlighting antagonistic pleiotropy and niche-dependent adaptation.

Noemi Santamaria de Souza
Yassine Cherrak
Wolf-Dietrich Hardt
ResearchOpen Access24 Feb 2025
Nature Communications

Volume: 16, P: 1-19
Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition

Acute systemic immune activation may affect gut-luminal colonisation dynamics. Here, the authors show that LPS exposure in mice elevates gut-luminal oxygen species levels, inhibiting the microbiota and enabling pathogen growth through aerobic respiration.

Sanne Kroon
Dejan Malcic
Wolf-Dietrich Hardt
ResearchOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1-18
Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Stefan A. Fattinger
Petra Geiser
Mikael E. Sellin
ResearchOpen Access17 Mar 2021
Mucosal Immunology

Volume: 14, P: 615-629
Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

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Annika Hausmann
Desirée Böck
Wolf-Dietrich Hardt
ResearchOpen Access17 Jan 2020
Mucosal Immunology

Volume: 13, P: 530-544

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Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization

Context-dependent change in the fitness effect of (in)organic phosphate antiporter glpT during Salmonella Typhimurium infection

Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition

Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

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Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization

Context-dependent change in the fitness effect of (in)organic phosphate antiporter glpT during Salmonella Typhimurium infection

Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition

Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

Search

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