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Showing 1–3 of 3 results
Advanced filters: Author: Manjunatha M Venkataswamy Clear advanced filters
  • SAUCIE, a deep learning platform to analyze single-cell data across samples and platforms, allows information to be obtained from the internal layers of the network, which provides additional mechanistic understanding that can be used to further tune data analysis.

    • Matthew Amodio
    • David van Dijk
    • Smita Krishnaswamy
    Research
    Nature Methods
    Volume: 16, P: 1139-1145
  • New vaccine candidates are urgently needed for the control and prevention of Mycobacterium tuberculosis (Mtb) infection. Kari Sweeney and her colleagues now report that an attenuated strain of Mycobacterium smegmatis expressing the esx-3 genes from Mtb induces effective CD4+ T cell dependent immunity against infection with Mtb in mice. The study offers a new avenue for the identification of protective immunogens in Mtb infection and a candidate vaccine platform warranting further study.

    • Kari A Sweeney
    • Dee N Dao
    • William R Jacobs Jr
    Research
    Nature Medicine
    Volume: 17, P: 1261-1268