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Showing 1–4 of 4 results
Advanced filters: Author: Manon Eckhardt Clear advanced filters

  • A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

    • David E. Gordon
    • Gwendolyn M. Jang
    • Nevan J. Krogan
    Research
    Nature
    Volume: 583, P: 459-468

  • Using a multi-OMICS approach, Haas et al identify 54 human genes and 16 host-targeting chemical compounds that regulate influenza A virus infection in lung epithelial cells, including AHNAK and COBP1 which are also essential for SARS-CoV-2 infection.

    • Kelsey M. Haas
    • Michael J. McGregor
    • Nevan J. Krogan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-27

  • Actin histidine methyltransferase SETD3 is a host factor critical for the replication of enteroviruses. Here, the authors report the 3.5 Å cryoEM structure of SETD3 interacting with enterovirus CV-B3 2A protease, defining the actin-binding SET domain as essential for virus replication.

    • Christine E. Peters
    • Ursula Schulze-Gahmen
    • Nevan J. Krogan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • This Review outlines a broad, universal framework for systems biology applied to infectious disease research. From study design and omics data collection, analysis, visualization and interpretation to translational outcomes, the authors illustrate how systems biology can provide insights into host–pathogen relationships for the betterment of human health.

    • Manon Eckhardt
    • Judd F. Hultquist
    • Nevan J. Krogan
    Reviews
    Nature Reviews Genetics
    Volume: 21, P: 339-354