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Showing 1–13 of 13 results
Advanced filters: Author: Manuel D. Leonetti Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Ziwen Liu et al. report Cytoland, an approach to train robust models to virtually stain landmark organelles of cells and address the generalization gap of current models. The training pipeline, models and datasets are shared under open-source permissive licences.

    • Ziwen Liu
    • Eduardo Hirata-Miyasaki
    • Shalin B. Mehta
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 901-915

  • Sunshine et al. use Perturb-seq to study host dependencies of SARS-CoV-2 by inactivating host factors genetically and monitoring the course of infection by single-cell sequencing, characterizing global host phenotypes. They identified NFKBIA, EIF4E2 and EIF4H as strong host dependency factors.

    • Sara Sunshine
    • Andreas S. Puschnik
    • Marco Y. Hein
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Tagging proteins with fluorescent proteins is a powerful method for both imaging and non-imaging applications. Here the authors use the eleventh β-strand of sfGFP and sfCherry as epitope tags for multicolour imaging and amplified signals by tandem arrangement; shortness of the tag enabled introduction into genomic loci using CRISPR/Cas9.

    • Daichi Kamiyama
    • Sayaka Sekine
    • Bo Huang
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Split fluorescent proteins (FPs) have been widely used to visualise proteins in cells. Here the authors develop a screen for engineering new split FPs, and report a yellow-green split-mNeonGreen2 with reduced background, a red split-sfCherry2 for multicolour labeling, and its photoactivatable variant for super-resolution use.

    • Siyu Feng
    • Sayaka Sekine
    • Bo Huang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.

    • Theodore L. Roth
    • Cristina Puig-Saus
    • Alexander Marson
    Research
    Nature
    Volume: 559, P: 405-409