A practical and selective palladium-catalysed process for C(sp3)–H arylation of tertiary alkylamines is enabled by the use of a simple amino acid-derived ligand. The reaction combines a range of multifaceted tertiary alkylamines with readily available aryl-boronic acids to form γ-aryl tertiary alkylamines and can also be performed enantioselectively.
- Jesus Rodrigalvarez
- Manuel Nappi
- Matthew J. Gaunt
