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Showing 1–13 of 13 results
Advanced filters: Author: Manvendra K. Singh Clear advanced filters

  • The mechanism and physiological role of brain-expressed Erythropoietin (EPO) is unclear. Here, authors show that the trajectory of pyramidal neurons is maneuvered by EPO, befitting the neurogenic hypothesis of alleviating mood, memory, and cognition.

    • Manvendra Singh
    • Ying Zhao
    • Hannelore Ehrenreich
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Non-ischemic cardiomyopathy is a severe disease, characterized by interstitial fibrosis in the left ventricle of the heart. Here authors show that the E3 ubiquitin ligase WWP2 plays a pathogenic role in heart fibrosis via regulating a distinct monocyte population that initiates the process.

    • Huimei Chen
    • Gabriel Chew
    • Enrico Petretto
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggesting a new target for manipulating angiogenesis.

    • Mao Wang
    • Patrick Sips
    • Stuart A Cook
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Abnormalities in how pulmonary veins connect to the heart underlie a type of congenital heart disease. Jonathan Epstein and his colleagues show that this condition, termed anomalous pulmonary venous connections, can be caused by mutation of the gene encoding the guidance protein semaphorin 3d and show how this protein acts in the embryo to pattern the developing pulmonary veins.

    • Karl Degenhardt
    • Manvendra K Singh
    • Jonathan A Epstein
    Research
    Nature Medicine
    Volume: 19, P: 760-765

  • The transcriptional regulator Tbx15 has a role in organ development. Here Lee et al.show that Tbx15 influences fibre-type determination in murine skeletal muscles, explaining local and systemic metabolic derangements in heterozygous Tbx15 knockout mice.

    • Kevin Y. Lee
    • Manvendra K. Singh
    • C. Ronald Kahn
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • lt has been debated for decades if there is a genetic aetiology underlying Möbius syndrome, a neurological disorder characterized by facial paralysis. Here Tomas-Roca et al. use exome sequencing and identify de novo mutations in PLXND1 and REV3L, representing converging pathways in hindbrain development.

    • Laura Tomas-Roca
    • Anastasia Tsaalbi-Shtylik
    • Hans van Bokhoven
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • An extensive analysis of HERVH (a primate-specific endogenous retrovirus) expression in human pluripotent stem cells is presented, identifying a sub-population of cells within cultured human embryonic stem cells and induced pluripotent stem cells that has characteristics of naive-state cells — the study provides evidence for a new primate-specific transcriptional circuitry regulating pluripotency.

    • Jichang Wang
    • Gangcai Xie
    • Zsuzsanna Izsvák
    Research
    Nature
    Volume: 516, P: 405-409