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Showing 1–2 of 2 results
Advanced filters: Author: María G Kuba Clear advanced filters

  • Most studies of autism spectrum disorder (ASD) have focused on neuronal mechanisms. Here, the authors describe vascular impairments in a mouse model of 16p11.2 deletion syndrome using physiological and genetic approaches to examine endothelial-dependent phenotypes.

    • Julie Ouellette
    • Xavier Toussay
    • Baptiste Lacoste
    Research
    Nature Neuroscience
    Volume: 23, P: 1090-1101

  • By digital profiling of residual breast tumors after neoadjuvant therapy, the authors identify gene expression patterns that correspond with a higher risk of metastasis and recurrence. Activation of the Ras-ERK pathway through loss of DUSP4 confers therapy resistance that can be overcome by combined treatment with MEK inhibitors.

    • Justin M Balko
    • Rebecca S Cook
    • Carlos L Arteaga
    Research
    Nature Medicine
    Volume: 18, P: 1052-1059